Publication Name	World Journal of Clinical Oncology
Manuscript ID	19304
Country	United States

Received	2015-05-04 08:37
Peer-Review Started	2015-05-05 19:44
To Make the First Decision	2015-06-03 14:57
Return for Revision	2015-06-08 20:27
Revised
Second Decision	2015-07-14 15:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-23 17:10
Articles in Press	2015-07-23 17:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-28 14:41
Publish the Manuscript Online	2015-10-13 10:26

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Colon cancer and the epidermal growth factor receptor: Current treatment paradigms, the importance of diet, and the role of chemoprevention
Manuscript Source	Invited Manuscript
All Author List	Baldeep Pabla, Marc Bissonnette and Vani J Konda
Funding Agency and Grant Number
Corresponding Author	Dr. Vani J Konda, Center of Endoscopic Research and Therapeutics, Section of Gastroenterology, Department of Medicine, Knapp Center for Biomedical Discovery, the University of Chicago Medicine, 900 E. 57th Street, Room #9134, Chicago, IL 60637, United States. vkonda@medicine.bsd.uchicago.edu
Key Words	Chemoprevention; Colon cancer; Epidermal growth factor receptor; Western diet; Curcumin; Green tea; Ginseng
Core Tip	This review article will summarize the risk factors and current treatment paradigms for colorectal cancer, with an emphasis on the role of targeted chemotherapy and chemoprevention as they relate to epidermal growth factor receptor (EGFR) blockade. It will include an overview of the structure and function of EGFR as well as intracellular pathways regulated by its activity. It will discuss how various EGFR ligands are upregulated in the presence of Western diets that are high in saturated and N-6 unsaturated fat, and will outline the various mechanisms of EGFR inhibition observed with several naturally occurring chemopreventative agents including ginseng, green tea, and curcumin.
Publish Date	2015-10-13 10:26
Citation	Pabla B, Bissonnette M, Konda VJ. Colon cancer and the epidermal growth factor receptor: Current treatment paradigms, the importance of diet, and the role of chemoprevention. World J Clin Oncol 2015; 6(5): 133-141
URL	http://www.wjgnet.com/2218-4333/full/v6/i5/133.htm
DOI	http://dx.doi.org/10.5306/wjco.v6.i5.133

Full Article (PDF)	WJCO-6-133.pdf
Full Article (Word)	WJCO-6-133.doc
Manuscript File	19304-Review.docx
Answering Reviewers	19304-Answering reviewers.pdf
Audio Core Tip	19304-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	19304-Conflict-of-interest statement.pdf
Copyright License Agreement	19304-Copyright assignment.pdf
Peer-review Report	19304-Peer-review(s).pdf
Scientific Misconduct Check	19304-Scientific misconduct check.pdf
Scientific Editor Work List	19304-Scientific editor work list.pdf