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Publication Name World Journal of Gastroenterology
Manuscript ID 19440
Country China
2015-05-08 16:23
Peer-Review Started
2015-05-11 15:24
To Make the First Decision
2015-08-31 09:15
Return for Revision
2015-09-02 11:14
2015-09-17 11:32
Second Decision
2015-11-03 09:02
Accepted by Journal Editor-in-Chief
2015-11-04 09:36
Accepted by Company Editor-in-Chief
2015-11-19 16:29
Articles in Press
2015-11-19 16:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-31 08:52
Publish the Manuscript Online
2016-01-15 14:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Topic Highlights
Article Title Group Ⅱ p21-activated kinases as therapeutic targets in gastrointestinal cancer
Manuscript Source Invited Manuscript
All Author List Yang-Guang Shao, Ke Ning and Feng Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 90813038
National Natural Science Foundation of China 31271389
National Natural Science Foundation of China 31371424
National Natural Science Foundation of China 31171360
National Natural Science Foundation of China 81230077
Corresponding Author Feng Li, PhD, Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, No. 77 Puhe Road, Shenbei District, Shenyang 110122, Liaoning Province, China. fli@mail.cmu.edu.cn
Key Words Group Ⅱ p21-activated kinases; Signaling pathway; Gastrointestinal cancer; PAK4 inhibitor; Drug target
Core Tip Group Ⅱ p21-activated kinases (PAKs) (PAK4, 5 and 6) are pluripotent kinases that regulate many fundamental cellular processes, including cytoskeletal organization, cell cycle regulation, cell survival and cell adhesion, and have therefore been implicated in carcinogenesis and cancer progression. Members of the group Ⅱ PAKs, particularly PAK4, have emerged as attractive targets for the development of anticancer drugs. In this review, we summarize the latest findings on the biological activities of group Ⅱ PAKs, the important roles of group Ⅱ PAKs in gastrointestinal cancer and the current status of the development of small-molecule inhibitors of PAK4 for the treatment of cancer.
Publish Date 2016-01-15 14:54
Citation Shao YG, Ning K, Li F. Group Ⅱ p21-activated kinases as therapeutic targets in gastrointestinal cancer. World J Gastroenterol 2016; 22(3): 1224-1235
URL http://www.wjgnet.com/1007-9327/full/v22/i3/1224.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i3.1224
Full Article (PDF) WJG-22-1224.pdf
Full Article (Word) WJG-22-1224.doc
Manuscript File 19440-Review.doc
Answering Reviewers 19440-Answering reviewers.pdf
Audio Core Tip 19440-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 19440-Conflict-of-interest statement.pdf
Copyright License Agreement 19440-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 19440-Language certificate.pdf
Peer-review Report 19440-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 19440-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 19440-Scientific misconduct check.pdf
Scientific Editor Work List 19440-Scientific editor work list.pdf