Publication Name	World Journal of Experimental Medicine
Manuscript ID	19481
Country	United States

Received	2015-05-10 15:20
Peer-Review Started	2015-05-12 17:03
To Make the First Decision	2015-07-27 18:43
Return for Revision	2015-07-29 17:48
Revised	2015-08-03 11:18
Second Decision	2015-10-22 11:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-04 17:32
Articles in Press	2015-11-04 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-13 18:33
Publish the Manuscript Online	2015-11-23 08:36

ISSN	2220-315x (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis
Manuscript Source	Invited Manuscript
All Author List	Jean Huang, Rudruidee Karnchanasorn, Horng-Yih Ou, Wei Feng, Lee-Ming Chuang, Ken C Chiu and Raynald Samoa
Funding Agency and Grant Number
Corresponding Author	Ken C Chiu, MD, FACE, Department of Clinical Diabetes, Endocrinology, and Metabolism, City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010, United States. kchiu@coh.org
Key Words	Diabetes mellitus; Insulin sensitivity; Beta cell function; Ferritin; Liver
Core Tip	Hemochromatosis and excess iron load has been implicated to play a role in the pathogenesis of diabetes mellitus. Serum ferritin concentration was significantly higher in diabetic subjects. Serum ferritin concentration was negatively associated with insulin sensitivity, but not with beta cell function. The association of alanine aminotransferase correlated with serum ferritin concentration, but not insulin sensitivity, sug-gesting the role of the liver in iron-associated insulin resistance. Disordered iron metabolism could play a role in the pathogenesis of insulin resistance and type 2 diabetes mellitus through its effect on liver function.
Publish Date	2015-11-23 08:36
Citation	Huang J, Karnchanasorn R, Ou H-Y, Feng W, Chuang L-M, Chiu KC, Samoa R. Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis. World J Exp Med 2015; 5(4): 232-243
URL	http://www.wjgnet.com/2220-315X/full/v5/i4/232.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i4.232

Full Article (PDF)	WJEM-5-232.pdf
Full Article (Word)	WJEM-5-232.doc
Manuscript File	19481-Review.docx
Answering Reviewers	19481-Answering reviewers.pdf
Audio Core Tip	19481-Audio core tip.wma
Biostatistics Review Certificate	19481-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	19481-Conflict-of-interest statement.pdf
Copyright License Agreement	19481-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150510011447.pdf
Institutional Review Board Approval Form or Document	19481-Institutional review board statement.pdf
Peer-review Report	19481-Peer-review(s).pdf
Scientific Misconduct Check	19481-Scientific misconduct check.pdf
Scientific Editor Work List	19481-Scientific editor work list.pdf