| Category |
Immunology |
| Manuscript Type |
Autobiography |
| Article Title |
Restoring the Treg cell to Th17 cell ratio may alleviate HBV-related acute-on-chronic liver failure
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ying-Hua Niu, Dong-Lin Yin, Hong-Li Liu, Rui-Tian Yi, Yu-Cong Yang, Hong-An Xue, Tian-Yan Chen, Shu-Lin Zhang, Shu-Mei Lin and Ying-Ren Zhao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Major National Science and Technology Projects for Infectious Diseases (11th and 12th Five Year, China) |
2008ZX10002-007 |
| Major National Science and Technology Projects for Infectious Diseases (11th and 12th Five Year, China) |
2012ZX10002-007 |
| Foundation of Shaanxi Provincial Science and Technology Plan Projects |
2011K14-09-09 |
|
| Corresponding Author |
Dr. Ying-Ren Zhao, Professor of Medicine, Chief, Department of Infectious Diseases, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an 710061, Shaanxi Province, China. zhaoyingren@sohu.com
|
| Key Words |
Hepatitis B virus; Acute-on-chronic liver failure; Regulatory T cells; T helper 17 cells; Treg cell to Th17 cell ratio |
| Core Tip |
In this study, the expression of circulating Treg and Th17 cells in hepatitis B virus-related acute-on-chronic liver failure (ACLF), chronic hepatitis B (CHB), and normal controls (NC) was measured using flow cytometric analysis. The percentages of circulating Treg and Th17 cells in ACLF group increased significantly compared with that in CHB group and NC group. Furthermore, the ratio of Treg to Th17 cells increased significantly upon recovery. Our study suggests that the reverting ratio of Treg to Th17 cells at the follow-up phase of ACLF could maintain the immune system at a steady state in favour of good prognosis.
|
| Publish Date |
2013-07-13 17:01 |
| Citation |
Niu YH, Yin DL, Liu HL, Yi RT, Yang YC, Xue HA, Chen TY, Zhang SL, Lin SM, Zhao YR. Restoring the Treg cell to Th17 cell ratio may alleviate HBV-related acute-on-chronic liver failure. World J Gastroenterol 2013; 19(26): 4146-4154 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i26/4146.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i26.4146 |
