Publication Name	World Journal of Gastroenterology
Manuscript ID	19822
Country	Singapore

Received	2015-05-22 16:34
Peer-Review Started	2015-05-23 15:15
To Make the First Decision	2015-07-19 15:34
Return for Revision	2015-07-27 11:24
Revised	2015-09-10 17:34
Second Decision	2015-10-12 09:06
Accepted by Journal Editor-in-Chief	2015-10-12 20:52
Accepted by Company Editor-in-Chief	2015-10-20 09:51
Articles in Press	2015-10-20 09:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-26 16:57
Publish the Manuscript Online	2015-12-09 17:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1
Manuscript Source	Unsolicited Manuscript
All Author List	Weiqi Tan, Seng-Gee Lim and Theresa MC Tan
Funding Agency and Grant Number	Funding Agency Grant Number Biomedical Research Council and Ministry of Education (Tier 1) to Tan TM
Corresponding Author	Theresa MC Tan, Associate Professor, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore S117597, Singapore. bchtant@nus.edu.sg
Key Words	MicroRNA-210; Hepatocellular carcinoma; Proliferation; Yes1
Core Tip	In this study, miR-210 is significantly up-regulated in hepatocellular carcinoma (HCC). Over-expression of miR-210 decreased cell proliferation and delayed cell cycle progression of HCC cells. The tyrosine kinase Yes1 is shown to be a target of miR-210 and is down-regulated in HCC. Knock-down of Yes1 by siRNA also significantly reduced cell proliferation. These results increase the understanding of the multiple roles of miR-210 in liver cancer growth and metastasis.
Publish Date	2015-12-09 17:57
Citation	Tan W, Lim SG, Tan TMC. Up-regulation of microRNA-210 inhibits proliferation of hepatocellular carcinoma cells by targeting YES1. World J Gastroenterol 2015; 21(46): 13030-13041
URL	http://www.wjgnet.com/1007-9327/full/v21/i46/13030.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i46.13030

Full Article (PDF)	WJG-21-13030.pdf
Full Article (Word)	WJG-21-13030.doc
Manuscript File	19822-Review.docx
Answering Reviewers	19822-Answering reviewers.pdf
Audio Core Tip	19822-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	19822-Conflict of interest statement.pdf
Copyright License Agreement	19822-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	19822-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	19822-Institutional review board statement.pdf
Peer-review Report	19822-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	19822-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	19822-Scientific misconduct check.pdf
Scientific Editor Work List	19822-Scientific editor work list.pdf