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12/6/2015 1:18:00 PM | Browse: 1232 | Download: 1426
Publication Name World Journal of Gastroenterology
Manuscript ID 19995
Country/Territory Chile
Received
2015-05-27 08:30
Peer-Review Started
2015-05-29 15:21
To Make the First Decision
2015-07-14 11:48
Return for Revision
2015-07-24 16:39
Revised
2015-08-08 04:03
Second Decision
2015-10-10 18:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-10-13 18:12
Articles in Press
2015-10-13 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-12 15:45
Publish the Manuscript Online
2015-12-06 13:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis
Manuscript Source Invited Manuscript
All Author List Manuel A Valenzuela, Jimena Canales, Alejandro H Corvalán and Andrew FG Quest
Funding Agency and Grant Number
Funding Agency Grant Number
CONICYT-FONDAP project 15130011 (to Corvalánand AH and Quest AFG)
FONDECYT project 1151411 (to Corvalán AH)
CONICYT PhD fellowship award to Canales J
Corresponding Author Andrew FG Quest, PhD, Cellular Communication Laboratory, Center for Molecular Studies of the Cell, Advanced Center for Chronic Diseases, School of Medicine, Universidad de Chile, Av. Independencia 1027, Santiago 8380453, Chile. aquest@med.uchile.cl
Key Words Helicobacter pylori; Methylation; Gastric cancer; Epigenetics; MicroRNA
Core Tip Helicobacter pylori infection increases the risk of developing gastric cancer. Intestinal type gastric cancer is characterized by a histological cascade in which aberrant methylation of CpG islands and deregulation of microRNAs are observed. An exacerbated host response and bacterial virulence factors contribute to these epigenetic changes by enhancing DNA methyl transferase activity via nitric oxide production and silencing of tumor suppressor genes and miRNAs. Interestingly, methylated Reprimo DNA is detectable in blood samples and is potentially useful as an early detection marker. Finally, also the role of gamma glutamyl transpeptidase related mechanisms in the loss of the anti-apoptotic protein Survivin and gastric carcinogenesis is discussed.
Publish Date 2015-12-06 13:18
Citation Valenzuela MA, Canales J, Corvalán AH, Quest AFG. Helicobacter pylori-induced inflammation and epigenetic changes during gastric carcinogenesis. World J Gastroenterol 2015; 21(45): 12742-12756
URL http://www.wjgnet.com/1007-9327/full/v21/i45/12742.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i45.12742
Full Article (PDF) WJG-21-12742.pdf
Full Article (Word) WJG-21-12742.doc
Manuscript File 19995-Review.doc
Answering Reviewers 19995-Answering reviewers.pdf
Audio Core Tip 19995-Audio core tip.mp3
Copyright License Agreement 19995-Copyright assignment.pdf
Peer-review Report 19995-Peer-review(s).pdf
Scientific Misconduct Check 19995-Scientific misconduct check.pdf
Scientific Editor Work List 19995-Scientific editor work list.pdf