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Articles Published Processes
11/30/2015 9:07:00 AM | Browse: 923 | Download: 1189
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Received |
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2015-05-28 16:58 |
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Peer-Review Started |
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2015-05-28 22:24 |
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To Make the First Decision |
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2015-07-27 15:49 |
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Return for Revision |
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2015-08-04 11:22 |
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Revised |
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2015-08-27 15:50 |
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Second Decision |
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2015-09-21 17:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-10-08 18:14 |
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Articles in Press |
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2015-10-08 18:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-11-11 16:11 |
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Publish the Manuscript Online |
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2015-11-30 09:06 |
| ISSN |
2218-6255 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Respiratory System |
| Manuscript Type |
Minireviews |
| Article Title |
β2-adrenoceptor in obstructive airway diseases: Agonism, antagonism or both?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Daniel WS Tan, Jyi Lin Wong, Siew Teck Tie, John A Abisheganaden, Albert YH Lim and WS Fred Wong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Medical Research Council of Singapore |
NMRC/CBRG/0027/2012(In part) |
| NUHS Seed Fund |
R-184-000-238-112 |
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| Corresponding Author |
Dr. WS Fred Wong, Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, 16 Medical Drive, MD3 #04-01, Singapore 117600, Singapore. phcwongf@nus.edu.sg |
| Key Words |
β-adrenoceptors; β2-agonist; β-blocker; Inverse agonist; Heart failure; β-arrestin |
| Core Tip |
This review summarizes the effect and usage of β2-agonist in obstructive airway disease, addressing the benefits and potential risks of β2-agonist. The review also looks at the safety of β-blocker for cardiovascular disease in patients with obstructive airway disease. There is also emerging evidence that non-selective β-blockers with inverse agonism ironically can have long-term beneficial effects in obstructive airway disease beyond cardiovascular protection. Further trials are urgently needed in this field as it might lead to a dramatic turnaround in clinical practice for obstructive airway diseases as has already been seen in the usage of β-blockers for heart failure. |
| Publish Date |
2015-11-30 09:06 |
| Citation |
Tan DWS, Wong JL, Tie ST, Abisheganaden JA, Lim AYH, Wong WSF. β2-adrenoceptor in obstructive airway diseases: Agonism, antagonism or both? World J Respirol 2014; 5(3): 199-206 |
| URL |
http://www.wjgnet.com/2218-6255/full/v5/i3/199.htm |
| DOI |
http://dx.doi.org/10.5320/wjr.v5.i3.199 |
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