Publication Name	World Journal of Gastroenterology
Manuscript ID	20148
Country	Italy

Received	2015-05-29 10:09
Peer-Review Started	2015-06-01 14:49
To Make the First Decision	2015-06-23 15:05
Return for Revision	2015-06-26 17:49
Revised	2015-07-28 15:02
Second Decision	2015-09-28 16:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-09-30 10:30
Articles in Press	2015-09-30 10:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-10 19:30
Publish the Manuscript Online	2015-11-03 17:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Biology
Manuscript Type	Topic Highlights
Article Title	Non-coding landscapes of colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Marco Ragusa, Cristina Barbagallo, Luisa Statello, Angelo Giuseppe Condorelli, Rosalia Battaglia, Lucia Tamburello, Davide Barbagallo, Cinzia Di Pietro and Michele Purrello
Funding Agency and Grant Number
Corresponding Author	Marco Ragusa, PhD, BioMolecular, Genome and Complex Systems BioMedicine Unit (BMGS) - Section of Biology and Genetics G Sichel, Department of BioMedical Sciences and BioTechnology, University of Catania, Via Santa Sofia 87, 95123 Catania, Italy. mragusa@unict.it
Key Words	Colorectal cancer; MicroRNA; Long non-coding RNAs; Circular RNAs; Diagnosis; Prognosis; Therapy
Core Tip	For many decades the predominant view of molecular functioning of organisms stated that proteins represent the main regulators of genomes and their dysfunctions were the first cause of diseases. This protein-centred view was too simplistic to explain the complexity of cancer. In the last few years many studies have revealed that about 85% of our genome is pervasively transcribed, mainly as non-protein-coding RNAs (ncRNAs). The discovery of countless molecular alterations of ncRNAs related to cancer changed the paradigms of cancer biology. In this review, we report recent advances in the discovery of ncRNAs involved in Colorectal Cancer pathobiologies, and their potential applications in diagnosis, prognosis and therapy.
Publish Date	2015-11-03 17:31
Citation	Ragusa M, Barbagallo C, Statello L, Condorelli AG, Battaglia R, Tamburello L, Barbagallo D, Di Pietro C, Purrello M. Non-coding landscapes of colorectal cancer. World J Gastroenterol 2015; 21(41): 11709-11739
URL	http://www.wjgnet.com/1007-9327/full/v21/i41/11709.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i41.11709

Full Article (PDF)	WJG-21-11709.pdf
Full Article (Word)	WJG-21-11709.doc
Manuscript File	20148-Review.doc
Answering Reviewers	20148-Answering reviewers.pdf
Audio Core Tip	20148-Audio core tip.MP3
Copyright License Agreement	20148-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20148-Language certificate.pdf
Peer-review Report	20148-Peer-review(s).pdf
Scientific Misconduct Check	20148-Scientific misconduct check.pdf
Scientific Editor Work List	20148-Scientific editor work list.pdf