Publication Name	World Journal of Gastroenterology
Manuscript ID	20196
Country	Italy

Received	2015-05-29 20:38
Peer-Review Started	2015-06-03 16:38
To Make the First Decision	2015-07-14 11:59
Return for Revision	2015-07-27 19:30
Revised	2015-08-19 23:51
Second Decision	2015-11-09 08:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-01 09:06
Articles in Press	2015-12-01 09:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-16 11:50
Publish the Manuscript Online	2015-12-31 13:27

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Overview of hepatitis B virus mutations and their implications in the management of infection
Manuscript Source	Invited Manuscript
All Author List	Patrizia Caligiuri, Rita Cerruti, Giancarlo Icardi and Bianca Bruzzone
Funding Agency and Grant Number
Corresponding Author	Dr. Patrizia Caligiuri, Department of Health Sciences, University of Genoa, Largo R. Benzi 10, 16132 Genoa, Italy. patrizia.caligiuri@libero.it
Key Words	Hepatitis B virus; Mutations; Open reading frames; Molecular biology tools; Liver disease
Core Tip	Hepatitis B virus (HBV) is a global health problem, with almost 2 billion infected persons, many of whom deemed to develop chronic carrier state and eventually die from cirrhosis or liver cancer. Unlike in other DNA viruses, its high mutation rate and replicative capability arise considerable genetic variability, recently analyzed by molecular biology tools. HBV mutations occur in all four overlapping open reading frames encoding viral polymerase, surface antigen, core and X protein. Understanding the correlation between mutations and liver disease progression is crucial for an effective clinical management in HBV patients with resistance to antiviral drugs, hepatitis B surface antigen escape mutant, “occult” hepatitis and hepatocellular carcinoma.
Publish Date	2015-12-31 13:27
Citation	Caligiuri P, Cerruti R, Icardi G, Bruzzone B. Overview of hepatitis B virus mutations and their implications in the management of infection. World J Gastroenterol 2016; 22(1): 145-154
URL	http://www.wjgnet.com/1007-9327/full/v22/i1/145.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i1.145

Full Article (PDF)	WJG-22-145.pdf
Full Article (Word)	WJG-22-145.doc
Manuscript File	20196-Review.doc
Answering Reviewers	20196-Answering Reviewers.pdf
Audio Core Tip	20196-Audio core tip.mp3
Copyright License Agreement	20196-Copyright assignment.PDF
Peer-review Report	20196-Peer-review(s).pdf
Scientific Misconduct Check	20196-Scientific misconduct check.pdf
Scientific Editor Work List	20196-Scientific editor work list.pdf