Publication Name	World Journal of Nephrology
Manuscript ID	20286
Country	Greece

Received	2015-06-01 15:53
Peer-Review Started	2015-06-04 18:03
To Make the First Decision	2015-08-14 15:24
Return for Revision	2015-08-22 17:32
Revised	2015-09-23 04:21
Second Decision	2015-10-13 08:59
Accepted by Journal Editor-in-Chief	2015-10-13 15:03
Accepted by Company Editor-in-Chief	2015-10-27 17:59
Articles in Press	2015-10-27 17:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-28 16:39
Publish the Manuscript Online	2016-01-06 20:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Urology & Nephrology
Manuscript Type	Editorial
Article Title	Receptor activator of nuclear factor κB ligand/osteoprotegerin axis and vascular calcifications in patients with chronic kidney disease
Manuscript Source	Invited Manuscript
All Author List	Michalis Spartalis and Aikaterini Papagianni
Funding Agency and Grant Number
Corresponding Author	Aikaterini Papagianni, MD, PhD, Associate Professor, Department of Nephrology, Aristotle University of Thessaloniki, “Hippokration” General Hospital, Papanastasiou 50 Str, 54642 Thessaloniki, Greece. aikpapag@otenet.gr
Key Words	Arterial stiffness; Bone turnover; Chronic kidney disease; Osteoprotegerin; RANK ligand; Receptor activator nuclear factor κB; Vascular calcifications
Core Tip	Vascular calcifications are commonly observed in chronic kidney disease patients and recently mounting evidence suggest that Receptor activator of nuclear factor κB ligand/osteoprotegerin axis controls both bone metabolism and extra-osseous bone formation. Further studies are required to establish the role of these biomarkers as predictors of the presence and severity of vascular calcifications and of cardiovascular morbidity and mortality. Moreover, randomized clinical trials are needed to clarify whether inhibition of osteoclast activity will protect from vascular calcifications.
Publish Date	2016-01-06 20:46
Citation	Spartalis M, Papagianni A. Receptor activator of nuclear factor κB ligand/osteoprotegerin axis and vascular calcifications in patients with chronic kidney disease. World J Nephrol 2016; 5(1): 1-5
URL	http://www.wjgnet.com/2220-6124/full/v5/i1/1.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i1.1

Full Article (PDF)	WJN-5-1.pdf
Full Article (Word)	WJN-5-1.doc
Manuscript File	20286-Review.doc
Answering Reviewers	20286-Answering reviewers.pdf
Audio Core Tip	20286-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20286-Conflict-of-interest statement.pdf
Copyright License Agreement	20286-Copyright assignment.pdf
Peer-review Report	20286-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20286-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20286-Scientific misconduct check.pdf
Scientific Editor Work List	20286-Scientific editor work list.pdf