Publication Name	World Journal of Stem Cells
Manuscript ID	20353
Country	Jamaica

Received	2015-06-02 08:56
Peer-Review Started	2015-06-07 19:59
To Make the First Decision	2015-07-06 14:48
Return for Revision	2015-07-11 15:58
Revised	2015-09-11 00:58
Second Decision	2016-01-28 17:17
Accepted by Journal Editor-in-Chief	2016-01-29 08:42
Accepted by Company Editor-in-Chief	2016-02-16 08:48
Articles in Press	2016-02-16 08:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-29 11:32
Publish the Manuscript Online	2016-04-13 13:33

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Review
Article Title	Migration of bone marrow progenitor cells in the adult brain of rats and rabbits
Manuscript Source	Invited Manuscript
All Author List	Donnahue Dennie, Jean-Pierre Louboutin and David S Strayer
Funding Agency and Grant Number
Corresponding Author	Jean-Pierre Louboutin, MD, PhD, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, West Road, Kingston 7, Jamaica. jplouboutin@hotmail.com
Key Words	Stem cells; Bone marrow; Hippocampus; Cell therapy; SV40; Brain; Nestin; Doublecortin; Neurons; Development; Epilepsy; Seizures
Core Tip	It was previously thought that the development of new neurons did not take place in the adult brain of higher vertebrates. There has been substantial progress in understanding neurogenesis in the adult brain during the last decade, showing that neural progenitor cells can induce neurogenesis, mainly in three areas: Subventricular zone, subgranular zone of the hippocampal dentate gyrus, and olfactory bulb. More recently, it has been shown that bone marrow progenitor cells can participate in neurogenesis in the adult brain. In this review, we discuss the mechanisms of the migration, differentiation, and maturation of bone marrow progenitor cells in the adult brain. We also consider the increase of adult neurogenesis following experimental seizures, provided that neuroinflammation is decreased by reducing the expression of chemokines, and consequently the related migration of inflammatory cells into the brain parenchyma.
Publish Date	2016-04-13 13:33
Citation	Dennie D, Louboutin JP, Strayer DS. Migration of bone marrow progenitor cells in the adult brain of rats and rabbits. World J Stem Cells 2016; 8(4): 136-157
URL	http://www.wjgnet.com/1948-0210/full/v8/i4/136.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i4.136

Full Article (PDF)	WJSC-8-136.pdf
Full Article (Word)	WJSC-8-136.doc
Manuscript File	20353-Review.docx
Answering Reviewers	20353-Answering reviewers.pdf
Audio Core Tip	20353-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20353-Conflict-of-interest statement.pdf
Copyright License Agreement	20353-Copyright assignment.pdf
Peer-review Report	20353-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20353-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20353-Scientific misconduct check.pdf
Scientific Editor Work List	20353-Scientific editor work list.pdf