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Articles Published Processes
11/11/2015 1:33:00 PM | Browse: 1007 | Download: 1225
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Received |
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2015-06-04 09:24 |
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Peer-Review Started |
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2015-06-06 17:13 |
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To Make the First Decision |
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2015-08-31 08:54 |
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Return for Revision |
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2015-08-31 16:24 |
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Revised |
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2015-09-11 23:14 |
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Second Decision |
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2015-09-23 19:50 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-09-30 08:53 |
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Articles in Press |
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2015-09-30 08:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-10-23 11:06 |
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Publish the Manuscript Online |
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2015-11-11 13:34 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Clinical Neurology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: Advances in 2015
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Salvatore Monaco, Sara Mariotto, Sergio Ferrari, Massimiliano Calabrese, Gianluigi Zanusso, Alberto Gajofatto, Domenico Sansonno and Franco Dammacco |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministero della Salute, Italy |
RF-2011-02347955（ to Monaco S） |
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| Corresponding Author |
Salvatore Monaco, MD, Professor, Department of Neurological and Movement Sciences, University of Verona, Policlinico “G.B. Rossi”, Piazzale L.A. Scuro 10, 37134 Verona, Italy. salvatore.monaco@univr.it |
| Key Words |
Extra-hepatic manifestations; Hepatitis C virus syndrome; Hepatitis C virus; Neurocognitive impairment; Neuropsychiatric disorders; Proton magnetic resonance spectroscopy; Sleep disorder |
| Core Tip |
Neurocognitive dysfunction, sleep disturbance, depression, fatigue and reduced quality of life are common manifestations of chronic hepatitis C virus (HCV) infection. Neuropsychological performance is impaired in HCV patients, in the absence of structural brain alterations on conventional magnetic resonance imaging (MRI). Brain metabolic and microstructural changes are easily detected by in vivo proton magnetic resonance spectroscopy and perfusion-weighted/diffusion tensor MRI, enabling detection of brain dysfunction in clinically asymptomatic subjects. The regional distribution of metabolic changes indicates an exclusive involvement of telencephalic areas, but not the diencephalon or brainstem. HCV is likely to play a major pathogenic role in these disorders. |
| Publish Date |
2015-11-11 13:34 |
| Citation |
Monaco S, Mariotto S, Ferrari S, Calabrese M, Zanusso G, Gajofatto A, Sansonno D, Dammacco F. Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: Advances in 2015. World J Gastroenterol 2015; 21(42): 11974-11983 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i42/11974.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i42.11974 |
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