Publication Name	World Journal of Methodology
Manuscript ID	20487
Country	Cyprus

Received	2015-06-07 14:50
Peer-Review Started	2015-06-07 15:43
To Make the First Decision	2015-09-28 11:27
Return for Revision	2015-10-05 17:28
Revised	2015-10-16 11:32
Second Decision	2015-12-03 17:35
Accepted by Journal Editor-in-Chief	2015-12-03 19:36
Accepted by Company Editor-in-Chief	2015-12-18 16:35
Articles in Press	2015-12-18 16:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-03 16:02
Publish the Manuscript Online	2016-03-18 09:50

ISSN	2222-0682 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Allergy
Manuscript Type	Editorial
Article Title	New developments and controversies in iron metabolism and iron chelation therapy
Manuscript Source	Invited Manuscript
All Author List	Christina N Kontoghiorghe and George J Kontoghiorghes
Funding Agency and Grant Number
Corresponding Author	George J Kontoghiorghes, PhD, Post­graduate Research Institute of Science, Technology, Environment and Medicine, 3 Ammochostou Street, Limassol 3021, Cyprus. kontoghiorghes.g.j@pri.ac.cy
Key Words	Iron metabolism; Iron chelation therapy; Deferiprone; Deferoxamine; Iron diseases; Deferasirox; Medical journals; Controversies
Core Tip	Abnormalities of iron metabolism including iron deficiency and overload affect more than a quarter of the world’s population. Iron also plays a major role in free radical pathology and associated tissue damage. Iron chelating drugs can override normal regulatory pathways, correct iron imbalance and minimise iron toxicity. Deferiprone and especially its combination with deferoxamine can completely treat iron overload in thalassaemia. Deferiprone can minimise the toxic effects of pathological iron in neurodegenerative, renal and other diseases. Controversies in the risk/benefit asse-ssment for the use of deferasirox in many conditions appear to involve commercial influence on academic journal and physicians.
Publish Date	2016-03-18 09:50
Citation	Kontoghiorghe CN, Kontoghiorghes GJ. New developments and controversies in iron metabolism and iron chelation therapy. World J Methodol 2016; 6(1): 1-19
URL	http://www.wjgnet.com/2222-0682/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.5662/wjm.v6.i1.1

Full Article (PDF)	WJM-6-1.pdf
Full Article (Word)	WJM-6-1.doc
Manuscript File	20487-Review.doc
Answering Reviewers	20487-Answering reviewers.pdf
Audio Core Tip	20487-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20487-Conflict-of-interest statement.pdf
Copyright License Agreement	20487-Copyright assignment.pdf
Peer-review Report	20487-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	20487-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	20487-Scientific misconduct check.pdf
Scientific Editor Work List	20487-Scientific editor work list.pdf