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12/6/2015 1:18:00 PM | Browse: 847 | Download: 1272
Publication Name World Journal of Gastroenterology
Manuscript ID 20693
Country/Territory Japan
Received
2015-06-16 10:15
Peer-Review Started
2015-06-19 09:25
To Make the First Decision
2015-07-10 14:37
Return for Revision
2015-07-13 19:58
Revised
2015-07-22 14:30
Second Decision
2015-09-13 22:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-15 14:03
Articles in Press
2015-09-15 14:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-12 11:18
Publish the Manuscript Online
2015-12-06 13:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury
Manuscript Source Unsolicited Manuscript
All Author List Naoki Sano, Takafumi Tamura, Naoyuki Toriyabe, Takeshi Nowatari, Ken Nakayama, Tomohito Tanoi, Soichiro Murata, Yu Sakurai, Mamoru Hyodo, Kiyoshi Fukunaga, Hideyoshi Harashima and Nobuhiro Ohkohchi
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Culture, Sports, Science, and Technology of Japan, KAKENHI 23390319
Corresponding Author Nobuhiro Ohkohchi, MD, PhD, Professor, Department of Surgery, Doctoral Program in Clinical Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, japan. nokochi3@md.tsukuba.ac.jp
Key Words Hyaluronic acid; Sphingosine 1-phosphate; Liver sinusoidal endothelial cell; Drug delivery system; Heme oxygenase-1; Stabilin-2
Core Tip We have developed a new formulation by directly combining hyaluronic acid and sphingosine 1-phosphate (HA-S1P), which targets liver sinusoidal endothelial cell (LSEC) by binding specifically to HA and HA receptors. This study demonstrated that HA-S1P protects the liver from hepatic ischemia/reperfusion (I/R) injury in rats. The strong protective effect of HA-S1P may be mediated by the anti-apoptotic effect of S1P on LSECs. These data indicate that HA-S1P is an effective agent for preventing hepatic I/R injury.
Publish Date 2015-12-06 13:18
Citation Sano N, Tamura T, Toriyabe N, Nowatari T, Nakayama K, Tanoi T, Murata S, Sakurai Y, Hyodo M, Fukunaga K, Harashima H, Ohkohchi N. New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. World J Gastroenterol 2015; 21(45): 12778-12786
URL http://www.wjgnet.com/1007-9327/full/v21/i45/12778.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i45.12778
Full Article (PDF) WJG-21-12778.pdf
Full Article (Word) WJG-21-12778.doc
Manuscript File 20693-Review.doc
Answering Reviewers 20693-Answering reviewers.pdf
Audio Core Tip 20693-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20693-Conflict-of-interest statement.pdf
Copyright License Agreement 20693-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 20693-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 20693-Institutional review board statement.pdf
Peer-review Report 20693-Peer-review(s).pdf
Scientific Editor Work List 20693-Scientific editor work list.pdf