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4/13/2016 8:23:00 AM | Browse: 842 | Download: 1134
Publication Name World Journal of Stem Cells
Manuscript ID 20720
Country/Territory Japan
2015-06-18 08:52
Peer-Review Started
2015-06-20 15:19
To Make the First Decision
2015-08-14 15:22
Return for Revision
2015-08-22 18:26
2015-09-17 21:49
Second Decision
2016-01-28 17:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-02-16 08:49
Articles in Press
2016-02-16 08:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-03-29 11:32
Publish the Manuscript Online
2016-04-13 13:33
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases
Manuscript Source Invited Manuscript
All Author List Chie Sugimoto, Hiroyoshi Fujita and Hiroshi Wakao
Funding Agency and Grant Number
Corresponding Author Hiroshi Wakao, PhD, Department of Hygiene and Cellular Preventive Medicine, Graduate School of Medicine, Hokkaido University, N15W7 Kita-ku, Sapporo 060-8638, Japan. hwakao@med.hokudai.ac.jp
Key Words Mucosal-associated invariant T cells; Induced pluripotent stem cells; Differentiation; Adoptive transfer; Inflammatory diseases; Autoimmune diseases; Disease modeling; Infectious diseases; Immunocompromised mouse
Core Tip Mucosal-associated invariant T (MAIT) cells, a novel innate-like T cell subset abundant in humans, play a pivotal role in immune-dysregulated diseases. However, MAIT cells are quite rare in laboratory mice and show poor proliferation in vitro. This makes it difficult to delineate their physiological functions in health and disease. Therefore, we developed a method to generate human MAIT cells from induced pluripotent stem cells [redifferentiation of MAIT (reMAIT) cells]. Given that reMAIT cells harbor characteristics quasi-identical to those found in MAIT cells from human peripheral blood, they will be useful to model human diseases in animals.
Publish Date 2016-04-13 13:33
Citation Sugimoto C, Fujita H, Wakao H. Mucosal-associated invariant T cells from induced pluripotent stem cells: A novel approach for modeling human diseases. World J Stem Cells 2016; 8(4): 158-169
URL http://www.wjgnet.com/1948-0210/full/v8/i4/158.htm
DOI http://dx.doi.org/10.4252/wjsc.v8.i4.158
Full Article (PDF) WJSC-8-158.pdf
Full Article (Word) WJSC-8-158.doc
Manuscript File 20720-Review.docx
Answering Reviewers 20720-Answering reviewers.pdf
Audio Core Tip 20720-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 20720-Conflict-of-interest statement.pdf
Copyright License Agreement 20720-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 20720-Language certificate.pdf
Peer-review Report 20720-Peer-review(s).pdf
Scientific Misconduct Check 20720-Scientific misconduct check.pdf
Scientific Editor Work List 20720-Scientific editor work list.pdf