Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	20970
Country	Italy

Received	2015-06-29 08:29
Peer-Review Started	2015-06-29 12:28
To Make the First Decision	2015-08-16 17:02
Return for Revision	2015-08-20 15:48
Revised	2015-09-19 19:33
Second Decision	2015-12-01 17:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-15 09:10
Articles in Press	2015-12-15 09:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-12 08:00
Publish the Manuscript Online	2016-01-19 16:11

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Endoscopic treatment of esophageal achalasia
Manuscript Source	Invited Manuscript
All Author List	Dario Esposito, Francesco Maione, Alessandra D’Alessandro, Giovanni Sarnelli and Giovanni D De Palma
Funding Agency and Grant Number
Corresponding Author	Giovanni D De Palma, MD, Director of Center of Excellence for Technical Innovation in Surgery, Department of Clinical Medicine and Surgery, University of Naples Federico Ⅱ, School of Medicine, via Pansini 5, 80131 Napoli, Italy. giovanni.depalma@unina.it
Key Words	Achalasia; High resolution manometry subtypes; Eckardt score; Per-oral endoscopic myotomy; Pneumatic dilatation; Botulin toxin; Myotomy
Core Tip	Achalasia is characterized by dysphagia, regurgitation, chest pain, weight loss and respiratory symptoms. Diagnosis and post-treatment assessment largely rely upon endoscopy, barium swallow study and high resolution esophageal manometry (HRM). Short term improvement in the symptomatology can be achieved with medical therapy or endoscopic botulin toxin injection. Long term relief from dysphagia can be obtained with either laparoscopic Heller myotomy, pneumatic dilatation or per-oral endoscopic myotomy. Age, sex, and manometric subtype by HRM are also predictors of responsiveness to treatment. Self-expandable metallic stents are an alternative in patients non responding to conventional therapies.
Publish Date	2016-01-19 16:11
Citation	Esposito D, Maione F, D’Alessandro A, Sarnelli G, De Palma GD. Endoscopic treatment of esophageal achalasia. World J Gastrointest Endosc 2016; 8(2): 30-39
URL	http://www.wjgnet.com/1948-5190/full/v8/i2/30.htm
DOI	http://dx.doi.org/10.4253/wjge.v8.i2.30

Full Article (PDF)	WJGE-8-30.pdf
Full Article (Word)	WJGE-8-30.doc
Manuscript File	20970-Review.docx
Answering Reviewers	20970-Answering reviewers.pdf
Audio Core Tip	20970-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	20970-Conflict-of-interest statement.pdf
Copyright License Agreement	20970-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	20970-Language certificate.pdf
Peer-review Report	20970-Peer-review(s).pdf
Scientific Misconduct Check	20970-Scientific misconduct check.pdf
Scientific Editor Work List	20970-Scientific editor work list.pdf