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11/11/2015 1:33:00 PM | Browse: 804 | Download: 1046
Publication Name World Journal of Gastroenterology
Manuscript ID 21061
Country/Territory Spain
2015-06-29 16:24
Peer-Review Started
2015-07-01 18:07
To Make the First Decision
2015-07-20 13:48
Return for Revision
2015-07-28 11:33
2015-08-17 21:56
Second Decision
2015-09-23 19:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-30 09:01
Articles in Press
2015-09-30 09:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-10-27 10:21
Publish the Manuscript Online
2015-11-11 13:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management
Manuscript Source Invited Manuscript
All Author List Sara Blasco-Algora, José Masegosa-Ataz, María Luisa Gutiérrez-García, Sonia Alonso-López and Conrado M Fernández-Rodríguez
Funding Agency and Grant Number
Corresponding Author Conrado M Fernandez-Rodriguez, MD, Service of Gastroenterology, Hospital Universitario Fundación, Alcorcón, Av Budapest-1, 28922 Alcorcón, Madrid, Spain. cfernandez@fhalcorcon.es
Key Words Acute on-chronic liver failure; Immune dysfunction; Systemic inflammatory response; Hepatic encephalopathy; Hepatorenal syndrome; Acute decompensation of cirrhosis; Liver failure; Organ failure; Severity score; Chronic liver failure-sequential organ failure assessment
Core Tip Acute on-chronic liver failure is a newly recognized syndrome characterized by acute deterioration of a compensated or decompensated chronic liver disease, leading to organ failure, and a mortality rate ≥ 15% at 28-d. Pathogenesis involves an exaggerated systemic inflammatory response in the setting of immune dysregulation and oxidative stress. Alcohol is a frequent precipitating factor seen most commonly in the West, and untreated hepatitis B virus infection is more prevalently seen in the East. However, it must be noted, that specific precipitant factors cannot be established in up to the 40% of cases. Recent prospective work has generated data on definition, prevalence, precipitating factors and scoring systems. Treatment of precipitant factors, complications, organ failure support, and liver transplantation are the current therapeutic options.
Publish Date 2015-11-11 13:34
Citation Blasco-Algora S, Masegosa-Ataz J, Gutiérrez-García ML, Alonso-López S, Fernández-Rodríguez CM. Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management. World J Gastroenterol 2015; 21(42): 12125-12140
URL http://www.wjgnet.com/1007-9327/full/v21/i42/12125.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i42.12125
Full Article (PDF) WJG-21-12125.pdf
Full Article (Word) WJG-21-12125.doc
Manuscript File 21061-Review.docx
Answering Reviewers 21061-Answering reviewers.pdf
Audio Core Tip 21061-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21061-Conflict-of-interest statement.pdf
Copyright License Agreement 21061-Copyright assignment.pdf
Peer-review Report 21061-Peer-review(s).pdf
Scientific Misconduct Check 21061-Scientific misconduct check.pdf
Scientific Editor Work List 21061-Scientific editor work list.pdf