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3/18/2016 2:28:00 PM | Browse: 638 | Download: 806
Publication Name World Journal of Transplantation
Manuscript ID 21166
Country/Territory Australia
Received
2015-06-30 15:39
Peer-Review Started
2015-07-04 17:37
To Make the First Decision
2015-10-08 16:39
Return for Revision
2015-10-16 15:30
Revised
2015-11-05 10:15
Second Decision
2015-12-17 18:34
Accepted by Journal Editor-in-Chief
2015-12-19 22:21
Accepted by Company Editor-in-Chief
2016-01-04 16:45
Articles in Press
2016-01-04 16:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-19 17:17
Publish the Manuscript Online
2016-03-18 14:28
ISSN 2220-3230 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Basic Study
Article Title Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation
Manuscript Source Invited Manuscript
All Author List Adrian D Hibberd, David A Clark, Paul R Trevillian and Patrick Mcelduff
Funding Agency and Grant Number
Funding Agency Grant Number
Kiriwina Investments Limited of Australia
Corresponding Author Adrian D Hibberd, MD, FRACS, FACS, Professor of Surgery, Newcastle Transplant Unit, Division of Surgery, John Hunter Hospital, Hunter Region Mail Centre, PO Box 1083, Newcastle, NSW 2310, Australia. adrian.hibberd@hnehealth.nsw.gov.au
Key Words Cardiac transplantation; Castanospermine; Cyclosporin A; Positive interaction; Mixed lymphocyte reaction
Core Tip The authors have established that a biological, castanospermine, interacts with cyclosporin A (CsA) in a synergistic manner when prolonging the survival of cardiac allografts in inbred rats. They suggest that the explanation is not its effect on the mixed lymphocyte reaction nor interference in the metabolism of CsA but rather an inhibition of migration through the basement membrane of the vasculature. They suggest that its effect on heparanase in mononuclear cells and heparan sulphate in the allograft should now be studied. This immunosuppressant holds promise of safe dose reduction of CsA but further assessment of its safety remains.
Publish Date 2016-03-18 14:28
Citation Hibberd AD, Clark DA, Trevillian PR, Mcelduff P. Interaction between castanospermine an immunosuppressant and cyclosporin A in rat cardiac transplantation. World J Transplant 2016; 6(1): 206-214
URL http://www.wjgnet.com/2220-3230/full/v6/i1/206.htm
DOI http://dx.doi.org/10.5500/wjt.v6.i1.206
Full Article (PDF) WJT-6-206.pdf
Full Article (Word) WJT-6-206.doc
Manuscript File 21166-Review.docx
Answering Reviewers 21166-Answering reviewers.pdf
Audio Core Tip 21166-Audio core tip.mp3
Biostatistics Review Certificate 21166-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 21166-Conflict-of-interest statement.pdf
Copyright License Agreement 21166-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 21166-Institutional animal care and use committee statement.pdf
Supplementary Material Supplementary_Material_20150629193312.eps
Peer-review Report 21166-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21166-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21166-Scientific misconduct check.pdf
Scientific Editor Work List 21166-Scientific editor work list.pdf