Publication Name	World Journal of Biological Chemistry
Manuscript ID	21169
Country	India

Received	2015-06-30 08:44
Peer-Review Started	2015-07-04 18:08
To Make the First Decision	2015-08-16 14:52
Return for Revision	2015-08-25 17:33
Revised	2015-09-04 18:40
Second Decision	2015-11-09 11:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-25 15:59
Articles in Press	2015-11-25 15:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 21:49
Publish the Manuscript Online	2016-02-25 19:30

ISSN	1949-8454 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials
Manuscript Source	Invited Manuscript
All Author List	Girish B Maru, Rasika R Hudlikar, Gaurav Kumar, Khushboo Gandhi and Manoj B Mahimkar
Funding Agency and Grant Number
Corresponding Author	Girish B Maru, PhD, Honorary Consu­ltant, Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre (TMC), Sector-22, Kharghar, Navi Mumbai 410210, India. gmaru@actrec.gov.in
Key Words	Cancer prevention; Dietary phytochemicals; Chemoprevention; Experimental efficacy; Mechanisms of action; Clinical trials; Bioavailability; Toxicity
Core Tip	Review compares the available evidence on the chemopreventive efficacy and probable mechanisms of chemoprevention by selected dietary phytochemicals in experimental systems and clinical trials. All the dietary phytochemicals covered have demonstrated chemopreventive efficacy against carcinogen-induced tumors in rodents at several organ sites. Mechanism of observed chemopreventive action(s) involve phy-tochemical-mediated redox changes, modulation of enzymes and signaling kinases leading to effects on multiple genes and cell signaling pathways. Clinical trials with these compounds have not demonstrated their chemopreventive efficacy. Probable reasons for observed mismatch between the two systems and areas of current research efforts and recommendations have been presented.
Publish Date	2016-02-25 19:30
Citation	Maru GB, Hudlikar RR, Kumar G, Gandhi K, Mahimkar MB. Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals: From experimental models to clinical trials. World J Biol Chem 2016; 7(1): 88-99
URL	http://www.wjgnet.com/1949-8454/full/v7/i1/88.htm
DOI	http://dx.doi.org/10.4331/wjbc.v7.i1.88

Full Article (PDF)	WJBC-7-88.pdf
Full Article (Word)	WJBC-7-88.doc
Manuscript File	21169-Review.docx
Answering Reviewers	21169-Answering reviewers.pdf
Audio Core Tip	21169-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21169-Conflict-of-interest statement.pdf
Copyright License Agreement	21169-Copyright assignment.pdf
Peer-review Report	21169-Peer-review(s).pdf
Scientific Misconduct Check	21169-Scientific misconduct check.pdf
Scientific Editor Work List	21169-Scientific editor work list.pdf