Publication Name	World Journal of Immunology
Manuscript ID	21282
Country	United States

Received	2015-07-03 08:17
Peer-Review Started	2015-07-09 17:27
To Make the First Decision	2015-09-16 09:13
Return for Revision	2015-09-22 17:36
Revised	2015-10-02 04:32
Second Decision	2015-11-12 14:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-11-25 16:08
Articles in Press	2015-11-25 16:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-24 18:00
Publish the Manuscript Online	2016-03-28 08:57

ISSN	2219-2824 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medical Laboratory Technology
Manuscript Type	Diagnostic Advances
Article Title	Syphilis testing algorithms: A review
Manuscript Source	Invited Manuscript
All Author List	Steven R Binder and Elitza S Theel
Funding Agency and Grant Number
Corresponding Author	Steven R Binder, Senior Director, Clinical Diagnostic Group, Bio-Rad Laboratories, Mailstop 4-225, 4000 Alfred Nobel Drive, Hercules, CA 94547, United States. steve_binder@bio-rad.com
Key Words	Syphilis; Treponemal infection; Immuno­assay; Reverse sequence screening; Rapid plasma regain; Treponema pallidum particle aggluti­nation test; Automation; Algorithm; Primary infection; Late latent infection
Core Tip	Many laboratories have adapted automated immunoassay methods for syphilis screening in the past decade. Since measurement of antibodies to Treponema pallidum (treponemal) antigens cannot readily distin-guish current from past infection, additional tests, including traditional non-treponemal tests, are required to further clarify the disease state. As the incidence of syphilis and population demographics influence test performance, and due to local differences in the way clinical follow-up is offered, there is no single approach to syphilis testing that is universally applicable.
Publish Date	2016-03-28 08:57
Citation	Binder SR, Theel ES. Syphilis testing algorithms: A review. World J Immunol 2016; 6(1): 1-8
URL	http://www.wjgnet.com/2219-2824/full/v6/i1/1.htm
DOI	http://dx.doi.org/10.5411/wji.v6.i1.1

Full Article (PDF)	WJI-6-1.pdf
Full Article (Word)	WJI-6-1.doc
Manuscript File	21282-Review.docx
Answering Reviewers	21282-Answering reviewers.pdf
Audio Core Tip	21282-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21282-Conflict-of-interest statement.pdf
Copyright License Agreement	21282-Copyright assignment.pdf
Peer-review Report	21282-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21282-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21282-Scientific misconduct check.pdf
Scientific Editor Work List	21282-Scientific editor work list.pdf