Publication Name	World Journal of Biological Chemistry
Manuscript ID	21290
Country	Switzerland

Received	2015-07-04 10:28
Peer-Review Started	2015-07-10 15:22
To Make the First Decision	2015-07-27 15:56
Return for Revision	2015-07-31 17:26
Revised	2015-09-04 21:59
Second Decision	2015-09-29 17:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-10-13 18:13
Articles in Press	2015-10-13 18:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-03 07:22
Publish the Manuscript Online	2015-11-23 10:19

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Review
Article Title	Modulation of the matrix redox signaling by mitochondrial Ca2+
Manuscript Source	Invited Manuscript
All Author List	Jaime Santo-Domingo, Andreas Wiederkehr and Umberto De Marchi
Funding Agency and Grant Number
Corresponding Author	Umberto De Marchi, PhD, Mitochondrial Function, Nestlé Institute of Health Sciences, EPFL Innovation Park, Batiment G, CH-1015 Lausanne, Switzerland. umberto.demarchi@rd.nestle.com
Key Words	Calcium transport; Signal transduction; Redox regulation; Mitochondria; Oxidation-reduction; Mitochondrial membrane transport proteins; Mitochondrial Ca2+ uniporter; Mitochondrial Na+/Ca2+ exchanger
Core Tip	Deregulated redox signaling in mitochondria leads to mitochondrial dysfunction, associated with several disorders and disease states. Matrix Ca2+ rising can be linked through multiple pathways to the mitochondrial redox state. Here we describe recent progress in the field of mitochondrial Ca2+ handling. We further summarize how mitochondrial Ca2+ signals are influencing the mitochondrial redox state. This link between Ca2+ and redox signals is likely of central importance in the regulation of mitochondrial function in health and disease.
Publish Date	2015-11-23 10:19
Citation	Santo-Domingo J, Wiederkehr A, De Marchi U. Modulation of the matrix redox signaling by mitochondrial Ca2+. World J Biol Chem 2015; 6(4): 310-323
URL	http://www.wjgnet.com/1949-8454/full/v6/i4/310.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i4.310

Full Article (PDF)	WJBC-6-310.pdf
Full Article (Word)	WJBC-6-310.doc
Manuscript File	21290-Review.docx
Answering Reviewers	21290-Answering reviewers.pdf
Audio Core Tip	21290-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21290-Conflict-of-interest statement.pdf
Copyright License Agreement	21290-Copyright assignment.pdf
Peer-review Report	21290-Peer-review(s).pdf
Scientific Misconduct Check	21290-Scientific misconduct check.pdf
Scientific Editor Work List	21290-Scientific editor work list.pdf