ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Role of CD56-expressing immature biliary epithelial cells in biliary atresia
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Rui-Zhong Zhang, Jia-Kang Yu, Jiao Peng, Feng-Hua Wang, Hai-Ying Liu, Vincent CH Lui, John M Nicholls, Paul KH Tam, Jonathan R Lamb, Yan Chen and Hui-Min Xia |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
State Clinical Key Specialty Construction Project (Pediatric Surgery) 2013 |
GJLCZD1301 |
Guangdong Provincial Science and Technology Plan Projects 2014 |
2014A020212373 |
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Corresponding Author |
Yan Chen, PhD, Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong province, China. ychenc@hku.hk
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Key Words |
Biliary atresia; CD56; epithelial cell adhesion molecule; cytokeratin 7; Biliary epithelial cells; Liver fibrosis |
Core Tip |
Clinical laboratory parameters did not correlate with tissue fibrosis in patients with biliary atresia (BA). Immunohistochemical staining showed that CD56-positive immature bile ducts were present only in patients with BA but not in those with choledochal cyst or neonatal hepatitis. The number of CD56 expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage. Furthermore, the signaling molecule Notch1, but not Notch2, was co-expressed in CD56 positive cells. Our data provide new insights into the pathogenesis of BA in terms of biliary epithelial cell maturation and Notch expression.
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Publish Date |
2016-02-25 19:03 |
Citation |
Zhang RZ, Yu JK, Peng J, Wang FH, Liu HY, Lui VCH, Nicholls JM, Tam PKH, Lamb JR, Chen Y, Xia HM. Role of CD56-expressing immature biliary epithelial cells in biliary atresia. World J Gastroenterol 2016; 22(8): 2545-2557 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i8/2545.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i8.2545 |