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Publication Name World Journal of Gastroenterology
Manuscript ID 2168
Country/Territory China
Received
2013-02-02 16:21
Peer-Review Started
2013-02-04 22:22
To Make the First Decision
2013-03-18 15:21
Return for Revision
2013-03-19 22:32
Revised
Second Decision
2013-06-19 12:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-06-20 00:52
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-23 19:32
Publish the Manuscript Online
2013-08-06 09:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses
Manuscript Source Invited Manuscript
All Author List Qian-Qian Chen, Li Yan, Chang-Zheng Wang, Wei-Hua Wang, Hui Shi, Bin-Bin Su, Qing-Huan Zeng, Hai-Tao Du and Jun Wan
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81050027
Corresponding Author Jun Wan, MD, Professor, Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fu Xing Road, Haidian District, Beijing 100853, China. wanjun301@126.com
Key Words Mesenchymal stem cells; Transplantation; Inflammatory bowel disease; Inflammatory response; Immunomodulation; Trinitrobenzene sulfonic acid colitis; Therapy
Core Tip In this study, the following factors were identified: (1) The differentiation of intestinal stem cells in injured gut was determined by detecting Lgr5+ cells; (2) Th1-Th2-Th17-Tregs-related inflammatory and immune cytokine expressions in serum and local intestinal tissues were determined; (3) A Th2 shift and correction of the imbalanced Th17/Tregs were found; (4) Master regulators of Th1, Th2, Th17 and Tregs were detected in bone marrow mesenchymal stem cells -treated trinitrobenzene sulfonic acid-induced colitis; and (5) The passways of Th1-T-bet, Th2-GATA family of transcription factors 3, Th17-retinoid related orphan receptor gamma(t) and Tregs-Foxp3 which serve as important immunoregulators in the correction of immune disorders and enhance the healing of injured intestinal mucosa were identified.
Publish Date 2013-08-06 09:19
Citation Chen QQ, Yan L, Wang CZ, Wang WH, Shi H, Su BB, Zeng QH, Du HT, Wan J. Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. World J Gastroenterol 2013; 19(29): 4702-4717
URL http://www.wjgnet.com/1007-9327/full/v19/i29/4702.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i29.4702
Full Article (PDF) WJG-19-4702.pdf
Manuscript File 2168-edited.doc
Answering Reviewers 2168-Answering reviewers.pdf
Copyright License Agreement 2168-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 2168-Language certificate.pdf
Peer-review Report 2168-Peer review(s).pdf
Scientific Editor Work List 2168-Scientific editor work list.doc