Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	21889
Country	Italy

Received	2015-07-31 08:54
Peer-Review Started	2015-07-31 13:48
To Make the First Decision	2015-09-28 13:32
Return for Revision	2015-09-29 18:27
Revised	2015-10-13 15:26
Second Decision	2015-12-12 17:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-21 11:29
Articles in Press	2015-12-21 11:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-22 09:38
Publish the Manuscript Online	2016-01-28 14:57

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Hematology
Manuscript Type	Review
Article Title	Novel insights in the management of sickle cell disease in childhood
Manuscript Source	Invited Manuscript
All Author List	Lorenzo Iughetti, Elena Bigi and Donatella Venturelli
Funding Agency and Grant Number
Corresponding Author	Lorenzo Iughetti, Associate Professor of Pediatrics, Pediatric Unit, Department of Medical and Surgical Sciences for Mothers, Children and Adults, University of Modena and Reggio Emilia, via del Pozzo 71, 41124 Modena, Italy. iughetti.lorenzo@unimore.it
Key Words	Clinical management; Hydroxyurea; Sickle cell disease; Children; Hematopoietic stem-cell transplantation
Core Tip	The correct management of sickle cell disease (SCD) requires a comprehensive medical care. Both a wider use of hydroxyurea and an early treatment of pain in children are needed to improve long-term outcomes. Moreover, we report in details the possibility offered by hematopoietic stem cell transplantation as a future curative option for SCD patients.
Publish Date	2016-01-28 14:57
Citation	Iughetti L, Bigi E, Venturelli D. Novel insights in the management of sickle cell disease in childhood. World J Clin Pediatr 2016; 5(1): 25-34
URL	http://www.wjgnet.com/2219-2808/full/v5/i1/25.htm
DOI	http://dx.doi.org/10.5409/wjcp.v5.i1.25

Full Article (PDF)	WJCP-5-25.pdf
Full Article (Word)	WJCP-5-25.doc
Manuscript File	21889-Review.doc
Answering Reviewers	21889-Answering reviewers.pdf
Audio Core Tip	21889-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21889-Conflict-of-interest statement.pdf
Copyright License Agreement	21889-Copyright assignment.pdf
Peer-review Report	21889-Peer-review(s).pdf
Scientific Misconduct Check	21889-Scientific misconduct check.pdf
Scientific Editor Work List	21889-Scientific editor work list.pdf