Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	21992
Country	Bangladesh

Received	2015-08-31 08:59
Peer-Review Started	2015-09-05 21:43
To Make the First Decision	2015-11-24 14:53
Return for Revision	2015-11-30 14:27
Revised	2016-01-03 12:32
Second Decision	2016-02-18 11:57
Accepted by Journal Editor-in-Chief	2016-02-19 00:51
Accepted by Company Editor-in-Chief	2016-03-09 12:38
Articles in Press	2016-03-09 12:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-20 18:02
Publish the Manuscript Online	2016-05-12 16:59

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Insulin resistance in development and progression of nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Shahinul Alam, Golam Mustafa, Mahabubul Alam and Nooruddin Ahmad
Funding Agency and Grant Number
Corresponding Author	Shahinul Alam, Associate Professor, Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh. shahinul67@yahoo.com
Key Words	Nonalcoholic fatty liver disease; Insulin resistance; Metabolic syndrome; Diabetes; Nonalcoholic steatohepatitis
Core Tip	Insulin resistance is considered as the major contributor for the development and progression of nonalcoholic fatty liver disease (NAFLD). However, recent evidence that has shown that non-obese indivi-duals from developing countries are also affected by NAFLD, thus the conventional paradigm of NAFLD as the “hepatic manifestation of metabolic syndrome” has become outdated. Recent studies have highlighted novel pathophysiological mechanisms for the develop-ment and progression of NAFLD. Insulin resistance contributes to the disease process, but it is evident that environmental and genetic factors also contribute for development of necroinflammation and subsequent progression to fibrosis. This review provides a summary of current knowledge of the pathogenesis of NAFLD and discusses factors that dissociate insulin resistance from NAFLD.
Publish Date	2016-05-12 16:59
Citation	Alam S, Mustafa G, Alam M, Ahmad N. Insulin resistance in development and progression of nonalcoholic fatty liver disease. World J Gastrointest Pathophysiol 2016; 7(2): 211-217
URL	http://www.wjgnet.com/2150-5330/full/v7/i2/211.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i2.211

Full Article (PDF)	WJGP-7-211.pdf
Full Article (Word)	WJGP-7-211.doc
Manuscript File	21992-Review.docx
Answering Reviewers	21992-Answering reviewers.pdf
Audio Core Tip	21992-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21992-Conflict-of-interest statement.pdf
Copyright License Agreement	21992-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21992-Language certificate.pdf
Peer-review Report	21992-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21992-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21992-Scientific misconduct check.pdf
Scientific Editor Work List	21992-Scientific editor work list.pdf