| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Behzad Yeganeh, Adel Rezaei Moghadam, Javad Alizadeh, Emilia Wiechec, Seyed Moayed Alavian, Mohammad Hashemi, Bita Geramizadeh, Afshin Samali, Kamran Bagheri Lankarani, Martin Post, Payam Peymani, Kevin M Coombs and Saeid Ghavami |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Manitoba Start-up funds |
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| Manitoba Medical Service Foundation |
to Ghavami S |
| University of Manitoba Start-up Funds |
to Alizadeh J |
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| Corresponding Author |
Saeid Ghavami, PhD, Assistant Professor, Department of Human Anatomy and Cell Science, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg R3E 0J9, Room 104, Canada. saeid.ghavami@umanitoba.ca |
| Key Words |
Cell fate; Cell death; Hepatocyte; Viral infection; Endoplasmic reticulum stress |
| Core Tip |
For the first time, the current study has addressed the co-incidence of apoptosis, autophagy, and unfolded protein response in the liver tissue of hepatitis B and hepatitis C (HBV, and HCV) infected patients. The results showed that all of these events are activated at the same time by HBV and HCV infection in the liver. All of these pathways probably are involved in replication and pathogenesis of HBV and HCV infection; therefore their modulation would probably be beneficial for new therapeutic approaches in these diseases.
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| Publish Date |
2015-12-15 12:22 |
| Citation |
Yeganeh B, Rezaei Moghadam A, Alizadeh J, Wiechec E, Alavian SM, Hashemi M, Geramizadeh B, Samali A, Bagheri Lankarani K, Post M, Peymani P, Coombs KM, Ghavami S. Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response. World J Gastroenterol 2015; 21(47): 13225-13239 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i47/13225.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i47.13225 |
