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Articles Published Processes
3/28/2016 3:05:00 PM | Browse: 464 | Download: 1006
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Received |
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2015-09-11 17:10 |
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Peer-Review Started |
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2015-09-14 18:53 |
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To Make the First Decision |
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2016-01-13 08:36 |
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Return for Revision |
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2016-01-15 15:39 |
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Revised |
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Second Decision |
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2016-02-25 18:37 |
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Accepted by Journal Editor-in-Chief |
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2016-02-25 20:59 |
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Accepted by Company Editor-in-Chief |
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2016-03-02 07:57 |
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Articles in Press |
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2016-03-02 07:57 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-16 09:59 |
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Publish the Manuscript Online |
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2016-03-28 15:05 |
ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Case Control Study |
Article Title |
Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma
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Manuscript Source |
Invited Manuscript |
All Author List |
Atilla Engin, Ipek Isik Gonul, Ayse Basak Engin, Ahmet Karamercan, Aylin Sepici Dincel and Ayse Dursun |
Funding Agency and Grant Number |
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Corresponding Author |
Dr. Ayse Basak Engin, associate professor, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara,
Turkey. abengin@gmail.com
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Key Words |
Colorectal carcinoma; Tryptophan; Indoleamine-2; 3-dioxygen; Lymphovascular invasion; Lymph node metastasis |
Core Tip |
Colorectal cancer (CRC) is one of the major public health problems in the world. Clinicopathological findings of patients who died of recurrent CRC after resection revealed that approximately 14% of patients with lymph node negative CRC die because of the presence of unrecognizable tumor cells that are categorized as micrometastases. Tryptophan degrading enzyme, indoleamine-2,3-dioxygenase expression by tumor cells has been shown to be correlated with a poor clinical prognosis of colon cancer. Our data indicated that high total indoleamine-2,3-dioxygenase immunostaining score is a strong predictor for im-mune tolerance, lymphatic invasion and subsequent lymph node metastasis. Therefore, indoleamine-2,3-dioxygenase immunostaining might be recommended for histopathological evaluation of CRC cases.
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Publish Date |
2016-03-28 15:05 |
Citation |
Engin A, Gonul II, Engin AB, Karamercan A, Sepici Dincel A, Dursun A. Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma. World J Gastroenterol 2016; 22(13): 3592-3601 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i13/3592.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i13.3592 |
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