BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
3/28/2016 3:05:00 PM | Browse: 464 | Download: 1006
Publication Name World Journal of Gastroenterology
Manuscript ID 22469
Country/Territory Türkiye
Received
2015-09-11 17:10
Peer-Review Started
2015-09-14 18:53
To Make the First Decision
2016-01-13 08:36
Return for Revision
2016-01-15 15:39
Revised
Second Decision
2016-02-25 18:37
Accepted by Journal Editor-in-Chief
2016-02-25 20:59
Accepted by Company Editor-in-Chief
2016-03-02 07:57
Articles in Press
2016-03-02 07:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-03-16 09:59
Publish the Manuscript Online
2016-03-28 15:05
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Case Control Study
Article Title Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma
Manuscript Source Invited Manuscript
All Author List Atilla Engin, Ipek Isik Gonul, Ayse Basak Engin, Ahmet Karamercan, Aylin Sepici Dincel and Ayse Dursun
Funding Agency and Grant Number
Corresponding Author Dr. Ayse Basak Engin, associate professor, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara, Turkey. abengin@gmail.com
Key Words Colorectal carcinoma; Tryptophan; Indoleamine-2; 3-dioxygen; Lymphovascular invasion; Lymph node metastasis
Core Tip Colorectal cancer (CRC) is one of the major public health problems in the world. Clinicopathological findings of patients who died of recurrent CRC after resection revealed that approximately 14% of patients with lymph node negative CRC die because of the presence of unrecognizable tumor cells that are categorized as micrometastases. Tryptophan degrading enzyme, indoleamine-2,3-dioxygenase expression by tumor cells has been shown to be correlated with a poor clinical prognosis of colon cancer. Our data indicated that high total indoleamine-2,3-dioxygenase immunostaining score is a strong predictor for im-mune tolerance, lymphatic invasion and subsequent lymph node metastasis. Therefore, indoleamine-2,3-dioxygenase immunostaining might be recommended for histopathological evaluation of CRC cases.
Publish Date 2016-03-28 15:05
Citation Engin A, Gonul II, Engin AB, Karamercan A, Sepici Dincel A, Dursun A. Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma. World J Gastroenterol 2016; 22(13): 3592-3601
URL http://www.wjgnet.com/1007-9327/full/v22/i13/3592.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i13.3592
Full Article (PDF) WJG-22-3592.pdf
Full Article (Word) WJG-22-3592.doc
Manuscript File 22469-Review.doc
Answering Reviewers 22469-Answering reviewers.pdf
Audio Core Tip 22469-Audio core tip.mp3
Biostatistics Review Certificate 22469-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 22469-Conflict-of-interest statement.pdf
Copyright License Agreement 22469-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 22469-Grant application form.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20150911154625.pdf
Institutional Review Board Approval Form or Document 22469-Institutional review board statement.pdf
Peer-review Report 22469-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 22469-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 22469-Scientific misconduct check.pdf
Scientific Editor Work List 22469-Scientific editor work list.pdf