Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study
|
Manuscript Source |
Invited Manuscript |
All Author List |
Mariabeatrice Principi, Alfredo Di Leo, Maria Pricci, Maria Principia Scavo, Raffaella Guido, Sabina Tanzi, Domenico Piscitelli, Antonio Pisani, Enzo Ierardi, Maria Cristina Comelli and Michele Barone |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Wholly granted from R and D, CMD Pharma Limited, United Kingdom |
|
|
Corresponding Author |
Alfredo Di Leo, Professor, Chief of Gastroenterology Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy. b.principi@gmail.com |
Key Words |
Estrogen receptor-β; Estrogen receptor-α; Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; Sporadic adenomatous polyposis; Phytoestrogens; Insoluble fibers |
Core Tip |
Active dietary intervention, a mixture of phytoestrogens and insoluble fibers, was administered in patients with sporadic colonic adenomas in a randomized, double-blind placebo-controlled trial. Dietary supplementation induced an increase in estrogen receptor (ER)-β protein and the ER-β/ER-α ratio with a general trend towards an increase in epithelial proliferation and apoptosis. These results, even if limited by the small number of subjects and short period of dietary supplementation, suggest the possibility of an interaction with epithelial apoptosis by means of mediating ER-β levels. |
Publish Date |
2013-07-20 20:47 |
Citation |
Principi M, Di Leo A, Pricci M, Scavo MP, Guido R, Tanzi S, Piscitelli D, Pisani A, Ierardi E, Comelli MC, Barone M. Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study. World J Gastroenterol 2013; 19(27): 4325-4333 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i27/4325.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i27.4325 |