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9/15/2014 8:54:00 PM | Browse: 869 | Download: 942
Publication Name World Journal of Gastroenterology
Manuscript ID 2248
Country/Territory Italy
Received
2013-02-09 17:06
Peer-Review Started
2013-02-13 13:23
To Make the First Decision
2013-03-11 14:52
Return for Revision
2013-03-18 09:58
Revised
2013-04-18 00:51
Second Decision
2013-05-09 12:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-05-10 10:25
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-07-04 14:20
Publish the Manuscript Online
2013-07-20 20:47
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study
Manuscript Source Invited Manuscript
All Author List Mariabeatrice Principi, Alfredo Di Leo, Maria Pricci, Maria Principia Scavo, Raffaella Guido, Sabina Tanzi, Domenico Piscitelli, Antonio Pisani, Enzo Ierardi, Maria Cristina Comelli and Michele Barone
Funding Agency and Grant Number
Funding Agency Grant Number
Wholly granted from R and D, CMD Pharma Limited, United Kingdom
Corresponding Author Alfredo Di Leo, Professor, Chief of Gastroenterology Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy. b.principi@gmail.com
Key Words Estrogen receptor-β; Estrogen receptor-α; Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; Sporadic adenomatous polyposis; Phytoestrogens; Insoluble fibers
Core Tip Active dietary intervention, a mixture of phytoestrogens and insoluble fibers, was administered in patients with sporadic colonic adenomas in a randomized, double-blind placebo-controlled trial. Dietary supplementation induced an increase in estrogen receptor (ER)-β protein and the ER-β/ER-α ratio with a general trend towards an increase in epithelial proliferation and apoptosis. These results, even if limited by the small number of subjects and short period of dietary supplementation, suggest the possibility of an interaction with epithelial apoptosis by means of mediating ER-β levels.
Publish Date 2013-07-20 20:47
Citation Principi M, Di Leo A, Pricci M, Scavo MP, Guido R, Tanzi S, Piscitelli D, Pisani A, Ierardi E, Comelli MC, Barone M. Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study. World J Gastroenterol 2013; 19(27): 4325-4333
URL http://www.wjgnet.com/1007-9327/full/v19/i27/4325.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i27.4325
Full Article (PDF) WJG-19-4325.pdf
Manuscript File 2248-Review.doc
Answering Reviewers 2248-Answering reviewers.pdf
Copyright License Agreement 2248-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics Committee.doc
Non-Native Speakers of English Editing Certificate 2248-Language certificate.pdf
Peer-review Report 2248-Peer reviews.pdf
Scientific Editor Work List 2248-Scientific editor work list.doc