Publication Name	World Journal of Hepatology
Manuscript ID	22661
Country	Saudi Arabia

Received	2015-09-13 10:38
Peer-Review Started	2015-09-15 09:02
To Make the First Decision	2015-11-13 09:02
Return for Revision	2015-11-17 10:04
Revised	2015-12-04 01:43
Second Decision	2016-02-17 09:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-03-09 12:53
Articles in Press	2016-03-09 12:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-03-13 01:54
Typeset the Manuscript	2016-03-24 16:48
Publish the Manuscript Online	2016-03-30 15:59

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Shilu Mathew, Hany Abdel-Hafiz, Abbas Raza, Kaneez Fatima and Ishtiaq Qadri
Funding Agency and Grant Number	Funding Agency Grant Number STACK-Large grant 162-34(to Ishtiaq Qadri) IQ Foundation
Corresponding Author	Ishtiaq Qadri, PhD, Professor, King Fahd Medical Research Center, King Abdul Aziz University, PO Box 80216 Jeddah 21589, Saudi Arabia. ishtiaq80262@yahoo.com
Key Words	Hepatitis B virus; Hepatocellular carcinoma; Subtypes; Genetic polymorphism; Liver cirrhosis
Core Tip	In this review, we discuss various common associations between hepatitis B virus (HBV) and host polymorphisms. These single nucleotide polymorphisms which have been found to be associated with various genes still require validation in association studies in order to be considered good prognostic candidates for hepatocellular carcinoma (HCC). Screening of these polymorphisms is very beneficial in clinical experiments to stratify the higher or lower risk for HCC and may help in designing effective and efficient HCC surveillance programs for chronic HBV-infected patients if further genetic vulnerabilities are detected.
Publish Date	2016-03-30 15:59
Citation	Mathew S, Abdel-Hafiz H, Raza A, Fatima K, Qadri I. Host nucleotide polymorphism in hepatitis B virus-associated hepato­cellular carcinoma. World J Hepatol 2016; 8(10): 485-498
URL	http://www.wjgnet.com/1948-5182/full/v8/i10/485.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i10.485

Full Article (PDF)	WJH-8-485.pdf
Full Article (Word)	WJH-8-485.doc
Manuscript File	22661-Review.docx
Answering Reviewers	22661-Answering reviewers.pdf
Audio Core Tip	22661-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22661-Conflict-of-interest statement.pdf
Copyright License Agreement	22661-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22661-Grant application form(s).pdf
Peer-review Report	22661-Peer-review(s).pdf
Scientific Misconduct Check	22661-Scientific misconduct check.pdf
Scientific Editor Work List	22661-Scientific editor work list.pdf