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Publication Name World Journal of Pharmacology
Manuscript ID 22731
Country/Territory Australia
Received
2015-09-20 15:30
Peer-Review Started
2015-09-22 18:50
To Make the First Decision
2015-10-27 11:16
Return for Revision
2015-10-30 16:33
Revised
2015-11-26 15:41
Second Decision
2015-12-18 11:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-01-04 16:40
Articles in Press
2016-01-04 16:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-23 13:37
Publish the Manuscript Online
2016-03-04 15:35
ISSN 2220-3192 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Psychiatry
Manuscript Type Review
Article Title Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia
Manuscript Source Invited Manuscript
All Author List Shaun Hopper, Madhara Udawela, Elizabeth Scarr and Brian Dean
Funding Agency and Grant Number
Corresponding Author Shaun Hopper, MSc, the Florey Institute of Neuroscience and Mental Health, the University of Melbourne, Gate 11 Royal Parade, Melbourne, Victoria 3052, Australia. shaun.hopper@florey.edu.au
Key Words Central nervous system; Antipsychotic; Allosteric; Cholinergic; Schizophrenia; Mutagenesis; Cognition; Muscarinic
Core Tip Schizophrenia is a psychiatric disorder affecting approximately 1% of the world population. Current treatments inadequately redress the cognitive impairments associated with the disease. In light of that we discuss the role of the cholinergic system, in particular the muscarinic M1 receptor, in schizophrenia and cognition and how allosteric compounds are being developed to address this undertreated aspect of the disease. We also discuss and compile mutagenesis studies of the muscarinic M1 receptor and how they relate to allosteric binding and function.
Publish Date 2016-03-04 15:35
Citation Hopper S, Udawela M, Scarr E, Dean B. Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia. World J Pharmacol 2016; 5(1): 32-43
URL http://www.wjgnet.com/2220-3192/full/v5/i1/32.htm
DOI http://dx.doi.org/10.5497/wjp.v5.i1.32
Full Article (PDF) WJP-5-32.pdf
Full Article (Word) WJP-5-32.doc
Manuscript File 22731-Review.docx
Answering Reviewers 22731-Answering reviewers.pdf
Audio Core Tip 22731-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 22731-Conflict-of-interest statement.pdf
Copyright License Agreement 22731-Copyright assignment.pdf
Supplementary Material Supplementary_Material_20150919161435.docx
Peer-review Report 22731-Peer-review(s).pdf
Scientific Misconduct Check 22731-Scientific misconduct check.pdf
Scientific Editor Work List 22731-Scientific editor work list.pdf