Publication Name	World Journal of Gastroenterology
Manuscript ID	22782
Country	Poland

Received	2015-09-23 08:33
Peer-Review Started	2015-09-25 21:10
To Make the First Decision	2015-10-14 16:53
Return for Revision	2015-10-17 17:29
Revised	2015-11-06 04:30
Second Decision	2015-12-22 12:44
Accepted by Journal Editor-in-Chief	2015-12-24 14:42
Accepted by Company Editor-in-Chief	2015-12-30 17:35
Articles in Press	2015-12-30 17:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-01 10:20
Publish the Manuscript Online	2016-02-25 19:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Molecular alterations in gastric cancer with special reference to the early-onset subtype
Manuscript Source	Invited Manuscript
All Author List	Małgorzata Skierucha, Anya NA Milne, G Johan A Offerhaus, Wojciech P Polkowski, Ryszard Maciejewski and Robert Sitarz
Funding Agency and Grant Number	Funding Agency Grant Number Polish Ministry of Science and Higher Education N N402 423838
Corresponding Author	Robert Sitarz, MD, PhD, Department of Surgical Oncology, Medical University of Lublin, S. Staszica 11, 20-081 Lublin, Poland. r.sitarz@umlub.pl
Key Words	Gastric cancer; Early-onset gastric cancer; Molecular alterations; Chromosomal instability; Single-nucleotide polymorphism; Microsatellite instability; Epigenetic alterations; Loss of heterozygosity
Core Tip	There are numerous factors that may trigger gastric carcinogenesis. They include genetic susceptibility, acquired mutations and favourable environmental circumstances, which combine and multiply within the lifetime. Therefore, the incidence of gastric cancer is the highest among the elderly. Conversely, young patients are exposed to environmental carcinogens for a short period, so they are a reliable subgroup in which to study primary genetic alterations. This review provides a summary of the data published thus far concerning the molecular characteristics of gastric cancer and highlights the outstanding features of early-onset gastric cancer.
Publish Date	2016-02-25 19:03
Citation	Skierucha M, Milne ANA, Offerhaus GJA, Polkowski WP, Maciejewski R, Sitarz R. Molecular alterations in gastric cancer with special reference to the early-onset subtype. World J Gastroenterol 2016; 22(8): 2460-2474
URL	http://www.wjgnet.com/1007-9327/full/v22/i8/2460.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i8.2460

Full Article (PDF)	WJG-22-2460.pdf
Full Article (Word)	WJG-22-2460.doc
Manuscript File	22782-Review.docx
Answering Reviewers	22782-Answering reviewers.pdf
Audio Core Tip	22782-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22782-Conflict-of-interest statement.pdf
Copyright License Agreement	22782-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22782-Language certificate.pdf
Peer-review Report	22782-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22782-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22782-Scientific misconduct check.pdf
Scientific Editor Work List	22782-Scientific editor work list.pdf