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12/27/2015 2:34:00 PM | Browse: 1072 | Download: 1349
Publication Name World Journal of Hepatology
Manuscript ID 22790
Country/Territory China
Received
2015-09-24 08:33
Peer-Review Started
2015-09-26 20:07
To Make the First Decision
2015-10-21 08:59
Return for Revision
2015-10-29 09:02
Revised
2015-11-11 08:50
Second Decision
2015-12-02 13:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-11 16:58
Articles in Press
2015-12-11 16:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-22 11:16
Publish the Manuscript Online
2015-12-27 14:34
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Review
Article Title Crosstalk between innate and adaptive immunity in hepatitis B virus infection
Manuscript Source Invited Manuscript
All Author List Li Wang, Kai Wang and Zhi-Qiang Zou
Funding Agency and Grant Number
Funding Agency Grant Number
Yantai Science and Technology Plan Project 2012116
Corresponding Author Li Wang, PhD, Infectious Disease Hospital of Yantai, Huanshan Road 62, Zhifu District, Yantai 264001, Shandong Province, China. liliwang2200@163.com
Key Words Crosstalk; Hepatitis B virus; Innate immune; Adapative immune
Core Tip Hepatitis B virus (HBV) is poorly sensed by the innate immune system and can escape innate immune recognition at the early stage of infection. HBV-specific T-cell responses are timely and efficiently induced in acute self-limited infections but are deeply exhausted in chronic hepatitis B. The tolerogenic effect of the liver environment and the persistent exposure of T cells to high antigen loads play a key role in the pathogenesis of T-cell inhibition in chronic HBV infection. Combination of reduction of HBV and virus antigen loads and restoration of the anti-viral T-cell function may represent a strategy to cure chronic HBV infections.
Publish Date 2015-12-27 14:34
Citation Wang L, Wang K, Zou ZQ. Crosstalk between innate and adaptive immunity in hepatitis B virus infection. World J Hepatol 2015; 7(30): 2980-2991
URL http://www.wjgnet.com/1948-5182/full/v7/i30/2980.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i30.2980
Full Article (PDF) WJH-7-2980.pdf
Full Article (Word) WJH-7-2980.doc
Manuscript File 22790-Review.doc
Answering Reviewers 22790-Answering reviewers.pdf
Audio Core Tip 22790-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22790-Conflict-of-interest statement.pdf
Copyright License Agreement 22790-Copyright assignment.pdf
Peer-review Report 22790-Peer-review(s).pdf
Scientific Misconduct Check 22790-Scientific misconduct check.pdf
Scientific Editor Work List 22790-Scientific editor work list.pdf