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Articles Published Processes
7/6/2016 1:52:00 PM | Browse: 1085 | Download: 1848
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Received |
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2015-10-02 13:19 |
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Peer-Review Started |
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2015-10-09 17:52 |
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To Make the First Decision |
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2015-11-06 11:11 |
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Return for Revision |
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2015-11-10 10:35 |
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Revised |
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2015-11-24 17:18 |
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Second Decision |
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2016-02-17 09:14 |
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Accepted by Journal Editor-in-Chief |
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2016-02-17 21:59 |
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Accepted by Company Editor-in-Chief |
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2016-05-27 11:30 |
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Articles in Press |
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2016-05-27 11:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-06-30 14:00 |
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Publish the Manuscript Online |
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2016-07-06 13:52 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Role of bile acids in the regulation of the metabolic pathways
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hiroki Taoka, Yoko Yokoyama, Kohkichi Morimoto, Naho Kitamura, Tatsuya Tanigaki, Yoko Takashina, Kazuo Tsubota and Mitsuhiro Watanabe |
| Funding Agency and Grant Number |
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| Corresponding Author |
Mitsuhiro Watanabe, PhD, Professor of Graduate School of Media and Governance, Professor of Faculty of Environment and Information Studies, Graduate School of Media and Governance, Department of Environment and Information Studies, Keio University, tau42, 5322 Endo, Fujisawa, Kanagawa 252-0882, Japan. wmitsu@sfc.keio.ac.jp
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| Key Words |
Bile acids; TGR5/M-BAR; Farnesoid X receptor; Glucose metabolism; Energy metabolism; Lipid metabolism; Bariatric surgery; Microbiota; Incretin; Bile acid binding resin |
| Core Tip |
Bile acids (BAs) are important molecules that participate in various metabolic pathways. BA signaling mechanisms are attractive therapeutic targets of the metabolic syndrome. In this review, we show the mecha-nisms of controlling glucose, lipid and energy metabolism via BA signaling. Furthermore, the authors also describe how those basic scientific studies have been applied to the clinical setting. Particularly, bile acid binding resin (BABR) originally used to treat hypercholesterolemia also stimulates incretin secretion and improves glucose metabolism. In addition to BABR, the clinical application of farnesoid X receptor and TGR5/M-BAR agonists are ongoing for the treatment of metabolic syndrome. The effects of bariatric surgery on glycemic control are also associated with BA metabolism. |
| Publish Date |
2016-07-06 13:52 |
| Citation |
Taoka H, Yokoyama Y, Morimoto K, Kitamura N, Tanigaki T, Takashina Y, Tsubota K, Watanabe M. Role of bile acids in the regulation of the metabolic pathways. World J Diabetes 2016; 7(13): 260-270 |
| URL |
http://www.wjgnet.com/1948-9358/full/v7/i13/260.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v7.i13.260 |
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