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Publication Name World Journal of Hepatology
Manuscript ID 23196
Country/Territory United Kingdom
2015-10-29 09:03
Peer-Review Started
2015-11-03 16:14
To Make the First Decision
2015-11-24 14:19
Return for Revision
2015-11-30 14:16
2015-12-22 05:53
Second Decision
2016-01-25 14:48
Accepted by Journal Editor-in-Chief
2016-01-25 16:16
Accepted by Company Editor-in-Chief
2016-02-16 09:55
Articles in Press
2016-02-16 09:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-17 11:34
Publish the Manuscript Online
2016-03-03 11:05
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, General and Internal
Manuscript Type Minireviews
Article Title Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion
Manuscript Source Invited Manuscript
All Author List Christopher Valerio, Eleni Theocharidou, Andrew Davenport and Banwari Agarwal
Funding Agency and Grant Number
Corresponding Author Banwari Agarwal, MD, Intensive Care Unit, Royal Free Hospital, Royal Free Hampstead NHS Trust, University College London, Pond Street, London NW3 2QG, United Kingdom. banwari.agarwal@nhs.net
Key Words Human serum albumin; Human albumin solution; Critical illness; Cirrhosis; Resuscitation fluid; Large-volume paracentesis; Hepatorenal syndrome; Spontaneous bacterial peritonitis
Core Tip Human serum albumin has several important functions beyond being the principal protein in plasma. In disease states, albumin levels may not only be low but there may also be functional hypoalbuminaemia. This may explain why human albumin solution is helpful in treating the complications of cirrhosis whereas its role (as a volume expander) in critical illness remains limited. However, in the presence of cirrhosis or acute liver failure the restoration of functional albumin may be beneficial, even in critically ill patients. This still needs to be addressed in clinical trials.
Publish Date 2016-03-03 11:05
Citation Valerio C, Theocharidou E, Davenport A, Agarwal B. Human albumin solution for patients with cirrhosis and acute on chronic liver failure: Beyond simple volume expansion. World J Hepatol 2016; 8(7): 345-354
URL http://www.wjgnet.com/1948-5182/full/v8/i7/345.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i7.345
Full Article (PDF) WJH-8-345.pdf
Full Article (Word) WJH-8-345.doc
Manuscript File 23196-Review.docx
Answering Reviewers 23196-Answering reviewers.pdf
Audio Core Tip 23196-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 23196-Conflict-of-interest statement.pdf
Copyright License Agreement 23196-Copyright assignment.pdf
Peer-review Report 23196-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 23196-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 23196-Scientific misconduct check.pdf
Scientific Editor Work List 23196-Scientific editor work list.pdf