Publication Name	World Journal of Gastroenterology
Manuscript ID	23239
Country	China

Received	2015-11-02 08:41
Peer-Review Started	2015-11-02 08:44
To Make the First Decision	2015-11-27 16:47
Return for Revision	2015-11-30 09:18
Revised	2015-12-14 20:32
Second Decision	2015-12-29 08:01
Accepted by Journal Editor-in-Chief	2015-12-29 13:31
Accepted by Company Editor-in-Chief	2016-01-11 13:02
Articles in Press	2016-01-11 13:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-01-30 01:53
Typeset the Manuscript	2016-03-02 12:04
Publish the Manuscript Online	2016-03-28 15:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Analysis of tumor-infiltrating gamma delta T cells in rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Liang Rong, Ke Li, Rui Li, Hui-Min Liu, Rui Sun and Xiao-Yan Liu
Funding Agency and Grant Number
Corresponding Author	Rui Li, MD, Department of Gastro­enterology, the First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. rongliangrl@yeah.net
Key Words	Rectal cancer; T cells; Vδ1 T cells; Vδ2 T cells; Foxp3; Cytotoxicity
Core Tip	The percentage of tumor-infiltrating Vδ1 T cells in rectal cancer patients increased when T stage increased, whereas the percentage of tumor-infiltrating Vδ2 T cells in rectal cancer patients decreased as T stage increased. Vδ1 T cells from rectal cancer tissues had strong regulatory effects, and in rectal cancer tissues the main infiltrating gδ T cells were Vδ1 T cells. Although Vδ2 T cells from rectal cancer tissues have strong cytotoxic effects, there was little infiltration of Vδ2 T cells in rectal cancer tissues. Thus, an immunosuppressant microenvironment was formed in rectal cancer tissues, which may limit antitumor immunity and allow tumors in rectal cancer patients to evade immune surveillance.
Publish Date	2016-03-28 15:05
Citation	Rong L, Li K, Li R, Liu HM, Sun R, Liu XY. Analysis of tumor-infiltrating gamma delta T cells in rectal cancer. World J Gastroenterol 2016; 22(13): 3573-3580
URL	http://www.wjgnet.com/1007-9327/full/v22/i13/3573.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i13.3573

Full Article (PDF)	WJG-22-3573.pdf
Full Article (Word)	WJG-22-3573.doc
Manuscript File	23239-Review.docx
Answering Reviewers	23239-Answering reviewers.pdf
Audio Core Tip	23239-Audio core tip.3gpp
Biostatistics Review Certificate	23239-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	23239-Conflict-of-interest statement.pdf
Copyright License Agreement	23239-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20151101204408.jpg
Institutional Animal Care and Use Committee Approval Form or Document	23239-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	23239-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	23239-Language certificate.pdf
Peer-review Report	23239-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	23239-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	23239-Scientific misconduct check.pdf
Scientific Editor Work List	23239-Scientific editor work list.pdf