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Publication Name World Journal of Gastroenterology
Manuscript ID 23377
Country/Territory China
2015-11-26 08:56
Peer-Review Started
2015-11-26 16:53
To Make the First Decision
2015-12-30 16:39
Return for Revision
2015-12-30 17:29
2016-02-01 16:32
Second Decision
2016-02-19 09:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-03-02 08:11
Articles in Press
2016-03-02 08:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-03-08 16:50
Typeset the Manuscript
2016-04-01 17:23
Publish the Manuscript Online
2016-04-19 09:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats
Manuscript Source Unsolicited Manuscript
All Author List Dan-Dan Gao, Jia Fu, Bo Qin, Wen-Xiang Huang, Chun Yang and Bei Jia
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Chongqing cstc2012jjA10052
Young High-End Medical Reserve Personnel Training Plan Foundation of Chongqing, China
Corresponding Author Bei Jia, PhD, Chongqing Key Laboratory of Infectious Diseases and Parasitic Diseases, Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yu Zhong District, Chongqing 400016, China. beijia7410@163.com
Key Words Acute-on-chronic liver failure; Recombinant adenovirus; Hyper-interleukin-6; Hepatocyte growth factor; Inflammatory cytokines
Core Tip The purport of our study was to analyse the protective efficacy of recombinant adenovirus containing hyper-interleukin-6 (Hyper-IL-6, HIL-6) and hepatocyte growth factor (HGF) (Ad-HGF-HIL-6) compared to that of recombinant adenovirus HIL-6 or HGF (Ad-HIL-6 or Ad-HGF) in rats with acute-on-chronic liver failure (ACLF). In summary, our results suggest that Ad-HGF-HIL-6 may confer a more powerful protective effect against ACLF than do Ad-HGF or Ad-HIL-6 in rats and can restrain the secretion of diverse inflammatory cytokines and reduce the apoptosis of hepatocytes. Ad-HGF-HIL-6 is likely to be a feasible protective therapy for serious liver injury.
Publish Date 2016-04-19 09:42
Citation Gao DD, Fu J, Qin B, Huang WX, Yang C, Jia B. Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats. World J Gastroenterol 2016; 22(16): 4136-4148
URL http://www.wjgnet.com/1007-9327/full/v22/i16/4136.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i16.4136
Full Article (PDF) WJG-22-4136.pdf
Full Article (Word) WJG-22-4136.doc
Manuscript File 23377-Review.doc
Answering Reviewers 23377-Answering reviewers.pdf
Audio Core Tip 23377-Audio core tip.mp3
Biostatistics Review Certificate 23377-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 23377-Conflict-of-interest statement.pdf
Copyright License Agreement 23377-Copyright assignment.pdf
Data Sharing Statement 23377-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 23377-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 23377-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 23377-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 23377-Language certificate.pdf
Peer-review Report 23377-Peer-review(s).pdf
Scientific Misconduct Check 23377-Scientific misconduct check.pdf
Scientific Editor Work List 23377-Scientific editor work list.pdf