| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Mathematical & Computational Biology |
| Manuscript Type |
Case Control Study |
| Article Title |
Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Abdel-Rahman Nabawy Zekri, Amira Salah El-Din Youssef, Yasser Mabrouk Bakr, Reham Mohamed Gabr, Ola Sayed Ahmed, Mostafa Hamed Elberry, Ahmed Mahmoud Mayla, Mohamed Abouelhoda and Abeer A Bahnassy |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Cancer Institute, Cairo University, Cairo, Egypt |
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| Corresponding Author |
Abdel-Rahman Nabawy Zekri, PhD, Head, Molecular Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr Al-Aini street, Fom El-Khaleeg, Cairo 11976,
Egypt. ncizekri@yahoo.com
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| Key Words |
Mathematical model; Hepatocellular carcinoma; α-fetoprotein; Soluble intercellular adhesion molecule-1; β-catenin; Interleukin-8; Soluble tumor necrosis factor receptor Ⅱ; Proteasome |
| Core Tip |
Hepatocellular carcinoma is one of the most common liver malignancies. We sought to create a mathematical model from a panel of serum proteins (intercellular adhesion molecules, beta catenin, interleukin-8, the proteasome, and soluble tumor necrosis factor receptor Ⅱ) in combination with α-fetoprotein to aid in early detection of hepatocellular carcinoma. This panel was measured in 384 subjects infected with hepatitis C virus (HCV) as well as 95 healthy control subjects negative for HCV. Finally, we created mathematical models that may be valuable tools for the early detection of different statuses of liver disease co-occurring with HCV infection.
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| Publish Date |
2016-04-19 09:42 |
| Citation |
Zekri AR, Youssef AS, Bakr YM, Gabr RM, Ahmed OS, Elberry MH, Mayla AM, Abouelhoda M, Bahnassy AA. Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model. World J Gastroenterol 2016; 22(16): 4168-4182 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i16/4168.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i16.4168 |
