| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Diagnostic value of endothelial markers and HHV-8 staining in gastrointestinal Kaposi sarcoma and its difference in endoscopic tumor staging
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Naoyoshi Nagata, Toru Igari, Takuro Shimbo, Katsunori Sekine, Junichi Akiyama, Yohei Hamada, Hirohisa Yazaki, Norio Ohmagari, Katsuji Teruya, Shinichi Oka and Naomi Uemura |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Center for Global Health and Medicine |
21-101 |
|
| Corresponding Author |
Naoyoshi Nagata, MD, Department of Gastroenterology and Hepatology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, 162-8655, Tokyo, Japan. nnagata_ncgm@yahoo.co.jp
|
| Key Words |
Gastrointestinal Kaposi's sarcoma; Hematoxylin and eosin; CD31; CD34; D2-40; Human herpesvirus-8 |
| Core Tip |
Diagnosis of gastrointestinal Kaposi sarcoma (GI-KS) is important because treatment specifics depend on the extent of the disease. Endoscopic biopsy is a definitive diagnostic method for GI-KS, but its diagnostic accuracy has not been fully studied. In the current study, receiver operating characteristic area under the curve of hematoxylin and eosin (HE) staining, lymphatic and blood vessel endothelial cell markers, and HHV-8 was found to be high (> 0.80), and its accuracy tended to increase with endoscopic tumor staging. D2-40 will be useful for complementing HE staining in the diagnosis of GI-KS, especially in the upper GI tract and for polypoid appearance.
|
| Publish Date |
2013-06-20 16:34 |
| Citation |
Nagata N, Igari T, Shimbo T, Sekine K, Akiyama J, Hamada Y, Yazaki H, Ohmagari N, Teruya K, Oka S, Uemura N. Diagnostic value of endothelial markers and HHV-8 staining in gastrointestinal Kaposi sarcoma and its difference in endoscopic tumor staging. World J Gastroenterol 2013; 19(23): 3608-3614 |
| URL |
http://www.wjgnet.com/1007-9327/full/v19/i23/3608.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v19.i23.3608 |
