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Articles Published Processes
6/13/2016 9:08:00 AM | Browse: 1036 | Download: 1704
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Received |
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2016-01-10 17:11 |
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Peer-Review Started |
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2016-01-12 08:45 |
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To Make the First Decision |
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2016-03-01 09:13 |
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Return for Revision |
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2016-03-01 15:49 |
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Revised |
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2016-03-10 00:00 |
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Second Decision |
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2016-04-12 17:11 |
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Accepted by Journal Editor-in-Chief |
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2016-04-14 22:37 |
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Accepted by Company Editor-in-Chief |
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2016-04-22 16:27 |
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Articles in Press |
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2016-04-22 16:27 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-19 11:57 |
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Publish the Manuscript Online |
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2016-06-13 09:08 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Minireviews |
| Article Title |
Orthopedic disorders of the knee in hemophilia: A current concept review
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| Manuscript Source |
Invited Manuscript |
| All Author List |
E Carlos Rodriguez-Merchan and Leonard A Valentino |
| Funding Agency and Grant Number |
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| Corresponding Author |
E Carlos Rodriguez-Merchan, MD, PhD, Department of Orthopedic Surgery, La Paz University Hospital-IdiPaz, Paseo de la Castellana 261, 28046 Madrid, Spain. ecrmerchan@gmx.es
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| Key Words |
Hemophilia; Knee; Orthopedic problems; Prevention; Surgical treatment |
| Core Tip |
Hemophilia is an inherited bleeding disorder due to deficiency of factor Ⅷ (hemophilia A) or factor Ⅸ (hemophilia B) resulting in insufficient thrombin generation leading to recurrent intra-articular hemorr-hages (hemarthroses). Prevention of hemarthroses with intravenous infusions of the deficient protein from infancy to adulthood (primary prophylaxis) should be considered to achieve optimal outcomes. If factor replacement therapy (FRT) is insufficient, or if patients are not adherent to the prescribed regimen, recurrent hemarthroses results in chondrocyte apoptosis (cartilage degeneration) and hypertrophy of the synovium (syno-vitis). Many surgical interventions are available for the knee joint. For example, to treat synovitis recalcitrant to FRT, there are two primary orthopedic modalities: Radiosynovectomy and arthroscopic synovectomy. This article reviews the pathogenesis, diagnosis and treat-ment of hemophilic arthropathy of the knee. |
| Publish Date |
2016-06-13 09:08 |
| Citation |
Rodriguez-Merchan EC, Valentino LA. Orthopedic disorders of the knee in hemophilia: A current concept review. World J Orthop 2016; 7(6): 370-375 |
| URL |
http://www.wjgnet.com/2218-5836/full/v7/i6/370.htm |
| DOI |
http://dx.doi.org/10.5312/wjo.v7.i6.370 |
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