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8/9/2016 8:46:00 AM | Browse: 949 | Download: 1245
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 24855
Country/Territory Ethiopia
Received
2016-02-12 10:41
Peer-Review Started
2016-02-12 19:21
To Make the First Decision
2016-03-23 17:33
Return for Revision
2016-03-24 09:29
Revised
2016-04-15 15:13
Second Decision
2016-06-01 17:25
Accepted by Journal Editor-in-Chief
2016-06-01 23:23
Accepted by Company Editor-in-Chief
2016-06-16 11:57
Articles in Press
2016-06-16 11:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-07-26 15:12
Publish the Manuscript Online
2016-08-09 08:50
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Apoptotic pathways as a therapeutic target for colorectal cancer treatment
Manuscript Source Unsolicited Manuscript
All Author List Aman M Abraha and Ezra B Ketema
Funding Agency and Grant Number
Corresponding Author Ezra B Ketema, MSc, Department of Medical Biochemistry, College of Health Sciences, Mekelle University, Mekelle 1871, Ethiopia. aga.bely@gmail.com
Key Words Colorectal cancer; Apoptotic pathways; Drug resistance; Colorectal cancer therapies; Apoptosis
Core Tip Evasion of apoptosis has been established as a prominent hallmark of several human cancers, contributing to both tumor progression and chemo-resistance. In colorectal cancer development, the balance between the rates of cell growth and apoptosis that maintains intestinal epithelial cell homeostasis is impaired progressively. Recent studies indicated that failure of apoptosis may be an important factor in the evolution of colorectal cancer and its poor response to chemotherapy and radiation. We herein discussed the mechanisms of apoptosis, abnormal expression of apoptosis-related genes and future promises of apoptotic pathways as a therapeutic target for colorectal cancer chemoprevention and treatment.
Publish Date 2016-08-09 08:50
Citation Abraha AM, Ketema EB. Apoptotic pathways as a therapeutic target for colorectal cancer treatment. World J Gastrointest Oncol 2016; 8(8): 583-591
URL http://www.wjgnet.com/1948-5204/full/v8/i8/583.htm
DOI http://dx.doi.org/10.4251/wjgo.v8.i8.583
Full Article (PDF) WJGO-8-583.pdf
Full Article (Word) WJGO-8-583.doc
Manuscript File 24855-Review.docx
Answering Reviewers 24855-Answering reivewers.pdf
Audio Core Tip 24855-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 24855-Conflict-of-interest statement.pdf
Copyright License Agreement 24855-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 24855-Language certificate.pdf
Peer-review Report 24855-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 24855-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 24855-Scientific misconduct check.pdf
Scientific Editor Work List 24855-Scientific editor work list.pdf