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Articles Published Processes
4/29/2016 4:50:00 PM | Browse: 1158 | Download: 1183
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Received |
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2016-02-16 10:21 |
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Peer-Review Started |
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2016-02-17 17:02 |
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To Make the First Decision |
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2016-03-07 08:53 |
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Return for Revision |
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2016-03-09 11:23 |
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Revised |
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2016-03-10 15:27 |
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Second Decision |
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2016-03-31 10:23 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-04-07 15:55 |
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Articles in Press |
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2016-04-07 15:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-04-11 09:03 |
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Publish the Manuscript Online |
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2016-04-29 16:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Precore/core region mutations of hepatitis B virus related to clinical severity
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Hong Kim, Seoung-Ae Lee, Seung Yeon Do and Bum-Joon Kim |
| Funding Agency and Grant Number |
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| Corresponding Author |
Bum-Joon Kim, PhD, Department of Biomedical Sciences, Microbiology and Immunology, Liver Research Institute and Cancer Research Institute, College of Medicine, Seoul National University, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea. kbumjoon@snu.ac.kr
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| Key Words |
Hepatitis B virus infection; Precore/core mutations; Hepatocellular carcinoma; HBeAg serostatus; Disease severity |
| Core Tip |
The presence of several distinct types of mutations in HBV infections has been shown to contribute to the progression of liver disease in chronically infected patients. Although the relationships between single mutation types in the preC/C region and clinical severity have rarely been studied to date, it was recently reported that some preC/C mutations, particularly in the MHC class Ⅱ restricted region, are significantly correlated with hepatocellular carcinoma. Several preC/C mutations, including preC G1896A, are also related to HBeAg sero-negative status, which can affect the disease progression of chronic patients. Mutations such as I97F/L or P135Q, which inhibit core nucleocapsid formation, also contribute to disease progression by evading host innate immunity. In addition, the P5H/L/T mutation may lead to hepatocarcinogenesis by inducing the ER stress-ROS axis. In this review, we mainly focus on the clinical implications of the reported preC/C mutations.
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| Publish Date |
2016-04-29 16:50 |
| Citation |
Kim H, Lee SA, Do SY, Kim BJ. Precore/core region mutations of hepatitis B virus related to clinical severity. World J Gastroenterol 2016; 22(17): 4287-4296 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i17/4287.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i17.4287 |
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