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6/2/2016 3:32:00 PM | Browse: 914 | Download: 1774
Publication Name World Journal of Gastroenterology
Manuscript ID 25000
Country/Territory India
Received
2016-02-18 09:23
Peer-Review Started
2016-02-19 13:50
To Make the First Decision
2016-03-31 09:51
Return for Revision
2016-04-01 11:25
Revised
2016-04-26 12:26
Second Decision
2016-04-28 09:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-05-04 18:32
Articles in Press
2016-05-04 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-05-23 16:20
Publish the Manuscript Online
2016-06-02 15:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Basic Study
Article Title Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-Ⅱ expression on dendritic cells in chronic hepatitis C infection
Manuscript Source Invited Manuscript
All Author List Shallu Tomer, Yogesh K Chawla, Ajay Duseja and Sunil K Arora
Funding Agency and Grant Number
Funding Agency Grant Number
Council of Scientific and Industrial Research 27 (0262) 12/EMR-II
Corresponding Author Sunil K Arora, MSc, PhD, MNAMS, Professor, Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. arora.sunil@pgimer.edu.in
Key Words Dendritic cells; Hepatitis C; Non-responders; Negative regulators; major histocompatibility complex Class-Ⅱ genes
Core Tip The study was aimed to understand the mechanisms of dendritic cells dysfunction during chronic hepatitis C (CHC) infection. The findings highlight the association between different immune response genes and viral persistence in non-responders to antiviral therapy. Up regulation of negative regulators and down-regulation of molecules involved with antigen presentation seems to associate with non-responsiveness to antiviral therapy. Some novel pathways can be targeted to achieve better management of CHC patients.
Publish Date 2016-06-02 15:26
Citation Tomer S, Chawla YK, Duseja A, Arora SK. Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-Ⅱ expression on dendritic cells in chronic hepatitis C infection. World J Gastroenterol 2016; 22(22): 5173-5182
URL http://www.wjgnet.com/1007-9327/full/v22/i22/5173.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i22.5173
Full Article (PDF) WJG-22-5173.pdf
Full Article (Word) WJG-22-5173.doc
Manuscript File 25000-Review.docx
Answering Reviewers 25000-Answering reviewers.pdf
Audio Core Tip 25000-Audio core tip.mp3
Biostatistics Review Certificate 25000-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 25000-Conflict-of-interest statement.pdf
Copyright License Agreement 25000-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 25000-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160217204605.docx
Institutional Review Board Approval Form or Document 25000-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 25000-Language certificate.pdf
Peer-review Report 25000-Peer-review(s).pdf
Scientific Misconduct Check 25000-Scientific misconduct check.pdf
Scientific Editor Work List 25000-Scientific editor work list.pdf