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Articles Published Processes
5/30/2016 5:39:00 PM | Browse: 941 | Download: 1309
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Received |
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2016-02-23 08:44 |
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Peer-Review Started |
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2016-02-23 17:31 |
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To Make the First Decision |
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2016-03-07 09:11 |
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Return for Revision |
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2016-03-07 11:32 |
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Revised |
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2016-03-19 16:49 |
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Second Decision |
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2016-03-24 11:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2016-03-30 16:52 |
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Articles in Press |
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2016-03-30 16:53 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-05-04 17:00 |
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Publish the Manuscript Online |
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2016-05-30 17:40 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Usefulness of portal vein pressure for predicting the effects of tolvaptan in cirrhotic patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ai Nakagawa, Masanori Atsukawa, Akihito Tsubota, Chisa Kondo, Tomomi Okubo, Taeang Arai, Norio Itokawa, Yoshiyuki Narahara and Katsuhiko Iwakiri |
| Funding Agency and Grant Number |
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| Corresponding Author |
Masanori Atsukawa, MD, PhD, Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, 1715, Kamakari, Inzai, Chiba 270-1694, Japan. momogachi@yahoo.co.jp |
| Key Words |
Tolvaptan; V2 receptor antagonist; Portal vein pressure; Hepatic venous pressure gradient; Decompensated chirrosis |
| Core Tip |
To clarify the factors influencing the effect of tolvaptan, a V2 receptor antagonist, in patients with decompensated liver cirrhosis complicated by liquid retention, we conducted this study. As a result, hepatic venous pressure gradient (HVPG) was the only significant factor that influenced the weight loss effect of tolvaptan. The response rate was 87.5% (7/8) in patients with HVPG of 190 mmH2O or less, whereas it was only 12.5% (2/16) in those with HVPG of greater than 190 mmH2O. The present study suggests that tolvaptan in the treatment of liquid retention related to decompensated liver cirrhosis could be more effective for patients with lower portal vein pressure. |
| Publish Date |
2016-05-30 17:40 |
| Citation |
Nakagawa A, Atsukawa M, Tsubota A, Kondo C, Okubo T, Arai T, Itokawa N, Narahara Y, Iwakiri K. Usefulness of portal vein pressure for predicting the effects of tolvaptan in cirrhotic patients. World J Gastroenterol 2016; 22(21): 5104-5113 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i21/5104.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i21.5104 |
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