Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	25081
Country	Thailand

Received	2016-03-01 09:26
Peer-Review Started	2016-03-02 14:18
To Make the First Decision	2016-04-05 14:40
Return for Revision	2016-04-06 17:25
Revised	2016-04-09 19:38
Second Decision	2016-04-12 17:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-04-22 16:35
Articles in Press	2016-04-22 16:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-29 16:58
Publish the Manuscript Online	2016-07-08 09:44

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Retrospective Cohort Study
Article Title	Opioid-sparing effect of selective cyclooxygenase-2 inhibitors on surgical outcomes after open colorectal surgery within an enhanced recovery after surgery protocol
Manuscript Source	Invited Manuscript
All Author List	Varut Lohsiriwat
Funding Agency and Grant Number
Corresponding Author	Varut Lohsiriwat, MD, PhD, Associate Professor of Surgery, Division of Colon and Rectal Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang-Lung Road, Bangkok Noi, Bangkok 10700, Thailand. bolloon@hotmail.com
Key Words	Selective cyclooxygenase-2 inhibitor; Outcome; Colon surgery; Rectal surgery; Enhanced recovery after surgery; Opioid; Ileus; Non-steroidal anti-inflammatory drug; Pain
Core Tip	This comparative study validates the effectiveness of perioperative administration of oral selective cyclooxygenase-2 (COX-2) inhibitors as a part of multimodal analgesia in an enhanced recovery after surgery protocol to significantly reduce opioid requirement (but not pain score) after open colorectal surgery. Our findings also indicate that opioid-sparing effect of selective COX-2 inhibitor has some important clinical benefits including quicker gastrointestinal recovery and shorter hospitalization.
Publish Date	2016-07-08 09:44
Citation	Lohsiriwat V. Opioid-sparing effect of selective cyclooxygenase-2 inhibitors on surgical outcomes after open colorectal surgery within an enhanced recovery after surgery protocol. World J Gastrointest Oncol 2016; 8(7): 543-549
URL	http://www.wjgnet.com/1948-5204/full/v8/i7/543.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i7.543

Full Article (PDF)	WJGO-8-543.pdf
Full Article (Word)	WJGO-8-543.doc
Manuscript File	25081-Review.docx
Answering Reviewers	25081-Answering reviewers.pdf
Audio Core Tip	25081-Audio core tip.wav
Biostatistics Review Certificate	25081-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25081-Conflict-of-interest statement.pdf
Copyright License Agreement	25081-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160301020656.pdf
Institutional Review Board Approval Form or Document	25081-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25081-Language certificate.pdf
Peer-review Report	25081-Peer-review(s).pdf
Scientific Misconduct Check	25081-Scientific misconduct check.pdf
Scientific Editor Work List	25081-Scientific editor work list.pdf