Publication Name	World Journal of Gastroenterology
Manuscript ID	25188
Country	China

Received	2016-02-27 14:36
Peer-Review Started	2016-02-28 22:17
To Make the First Decision	2016-03-21 08:59
Return for Revision	2016-03-21 10:37
Revised	2016-03-29 22:33
Second Decision	2016-04-08 17:28
Accepted by Journal Editor-in-Chief	2016-04-09 13:20
Accepted by Company Editor-in-Chief	2016-04-15 14:12
Articles in Press	2016-04-15 14:12
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-04-26 21:36
Typeset the Manuscript	2016-05-18 14:51
Publish the Manuscript Online	2016-06-13 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Basic Study
Article Title	Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice
Manuscript Source	Invited Manuscript
All Author List	Hai-Mei Zhao, Rong Xu, Xiao-Ying Huang, Shao-Min Cheng, Min-Fang Huang, Hai-Yang Yue, Xin Wang, Yong Zou, Ai-Ping Lu and Duan-Yong Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81260595 National Natural Science Foundation of China 81460679 Project of Jiangxi University of Traditional Chinese Medicine JZYC15S13 Chinese Scholarship Council and Jiangxi Province as visiting scholar CSC: 201408360110 Chinese Scholarship Council and Jiangxi Province as visiting scholar CSC: 201408360106
Corresponding Author	Duan-Yong Liu, Associate professor, Science and Technology College, Jiangxi University of Traditional Chinese Medicine, 819 Xingwan Road, Nanchang 330004, Jiangxi Province, China. liuduanyong@163.com
Key Words	Curcumin; Regulatory T cells; Dendritic cells; Costimulatory molecules
Core Tip	The low level of regulatory T (Treg) cells plays an important role in pathogenic process of inflammatory bowel disease (IBD). In our and other previous studies, curcumin (Cur) can effectively attenuate inflammation in humans and animals with colitis. However, whether Cur can improve the level of Treg cells and the pathway by which Cur regulates Treg cells are unclear. In the present study, we have shown that Cur potentially modulates activation of dendritic cells to enhance the suppressive functions of Treg cells and promote the recovery of damaged colonic mucosa in IBD.
Publish Date	2016-06-13 09:14
Citation	Zhao HM, Xu R, Huang XY, Cheng SM, Huang MF, Yue HY, Wang X, Zou Y, Lu AP, Liu DY. Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice. World J Gastroenterol 2016; 22(23): 5374-5383
URL	http://www.wjgnet.com/1007-9327/full/v22/i23/5374.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i23.5374

Full Article (PDF)	WJG-22-5374.pdf
Full Article (Word)	WJG-22-5374.doc
Manuscript File	25188-Review.docx
Answering Reviewers	25188-Answering reviewers.pdf
Audio Core Tip	25188-Audio core tip.mp3
Biostatistics Review Certificate	25188-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25188-Conflict-of-interest statement.pdf
Copyright License Agreement	25188-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25188-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	25188-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	25188-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25188-Language certificate.pdf
Peer-review Report	25188-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25188-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25188-Scientific misconduct check.pdf
Scientific Editor Work List	25188-Scientific editor work list.pdf