Publication Name	World Journal of Gastroenterology
Manuscript ID	25254
Country	China

Received	2016-03-02 09:20
Peer-Review Started	2016-03-03 13:21
To Make the First Decision	2016-04-01 08:05
Return for Revision	2016-04-14 08:23
Revised	2016-04-14 08:43
Second Decision	2016-04-25 13:19
Accepted by Journal Editor-in-Chief	2016-04-28 01:10
Accepted by Company Editor-in-Chief	2016-05-04 18:07
Articles in Press	2016-05-04 18:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2016-05-09 09:18
Typeset the Manuscript	2016-05-24 10:50
Publish the Manuscript Online	2016-06-13 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Hai Li, Yan Chen, Shi Liu and Xiao-Hua Hou
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81270458 National Natural Science Foundation of China 81570488
Corresponding Author	Shi Liu, MD, Professor, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. shiliugao@yahoo.com
Key Words	Long-pulse gastric electrical stimulation; Interstitial cells of Cajal; Gastric emptying; IGF-1 pathway; Diabetes mellitus; Gastrointestinal motility disorders
Core Tip	Gastric electrical stimulation (GES) regulates gastric motility and protects the interstitial cells of Cajal (ICCs). However, the mechanisms underlying these processes have not been determined. In this study, we report that long-pulse GES with three different parameters protected ICCs and that the insulin-like growth factor 1 signaling pathway is probably involved in this process. One GES parameter (5.5 cpm, 300 ms, 4 mA) showed immense potential as a clinical application for applying long-pulse GES as the optimal parameter.
Publish Date	2016-06-13 09:14
Citation	Li H, Chen Y, Liu S, Hou XH. Long-pulse gastric electrical stimulation protects interstitial cells of Cajal in diabetic rats via IGF-1 signaling pathway. World J Gastroenterol 2016; 22(23): 5353-5363
URL	http://www.wjgnet.com/1007-9327/full/v22/i23/5353.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i23.5353

Full Article (PDF)	WJG-22-5353.pdf
Full Article (Word)	WJG-22-5353.doc
Manuscript File	25254-Review.doc
Answering Reviewers	25254-Answering reviewers.pdf
Audio Core Tip	25254-Audio core tip.mp3
Biostatistics Review Certificate	25254-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	25254-Conflict-of-interest statement.pdf
Copyright License Agreement	25254-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	25254-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	25254-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	25254-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	25254-Language certificate.pdf
Peer-review Report	25254-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	25254-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	25254-Scientific misconduct check.pdf
Scientific Editor Work List	25254-Scientific editor work list.pdf