BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
5/20/2016 11:59:00 AM | Browse: 1076 | Download: 1628
Publication Name World Journal of Cardiology
Manuscript ID 25317
Country/Territory United Kingdom
Received
2016-03-04 09:14
Peer-Review Started
2016-03-04 15:46
To Make the First Decision
2016-03-21 14:04
Return for Revision
2016-03-22 09:12
Revised
2016-04-04 21:59
Second Decision
2016-04-06 16:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-04-18 11:58
Articles in Press
2016-04-18 11:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-05-06 16:01
Publish the Manuscript Online
2016-05-20 11:59
ISSN 1949-8462 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cardiac & Cardiovascular Systems
Manuscript Type Basic Study
Article Title Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4
Manuscript Source Invited Manuscript
All Author List Azhar Maqbool, Emma J Spary, Iain W Manfield, Michaela Ruhmann, Lorena Zuliani-Alvarez, Filomena O Gamboa-Esteves, Karen E Porter, Mark J Drinkhill, Kim S Midwood and Neil A Turner
Funding Agency and Grant Number
Funding Agency Grant Number
British Heart Foundation CH/92005
Corresponding Author Azhar Maqbool, PhD, Lecturer in Cardiovascular Medicine, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Clarendon Way, Leeds LS2 9JT, United Kingdom. cvsam@leeds.ac.uk
Key Words Tenascin C; Matrix metalloproteinase; Toll-like receptor; Interleukin-6; Cardiac fibroblasts
Core Tip Tenascin C (TNC) is transiently expressed in cardiac tissue following acute myocardial infarction (MI) and MI patients with higher serum TNC levels have worse long term prognosis. This suggests that TNC is important in ventricular remodelling, although a functional role in this process is unclear. We report that TNC stimulates interleukin-6 synthesis in cardiac myofibroblasts, an effect mediated by toll-like receptor 4. As a growing body of evidence suggests that prolongation of the post-infarction inflammatory response results in worse remodelling and dysfunction this important observation may in part explain the mechanism by which TNC induces maladaptive ventricular remodelling following MI.
Publish Date 2016-05-20 11:59
Citation Maqbool A, Spary EJ, Manfield IW, Ruhmann M, Zuliani-Alvarez L, Gamboa-Esteves FO, Porter KE, Drinkhill MJ, Midwood KS, Turner NA. Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4. World J Cardiol 2016; 8(5): 340-350
URL http://www.wjgnet.com/1949-8462/full/v8/i5/340.htm
DOI http://dx.doi.org/10.4330/wjc.v8.i5.340
Full Article (PDF) WJC-8-340.pdf
Full Article (Word) WJC-8-340.doc
Manuscript File 25317-Review.doc
Answering Reviewers 25317-Answering reviewers.pdf
Audio Core Tip 25317-Audio core tip.mp3
Biostatistics Review Certificate 25317-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 25317-Conflict-of-interest statement.pdf
Copyright License Agreement 25317-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 25317-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160303202135.docx
Institutional Animal Care and Use Committee Approval Form or Document 25317-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 25317-Institutional review board statement.pdf
Peer-review Report 25317-Peer-review(s).pdf
Scientific Misconduct Check 25317-Scientific misconduct check.pdf
Scientific Editor Work List 25317-Scientific editor work list.pdf