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Articles Published Processes
8/17/2016 8:44:00 AM | Browse: 1028 | Download: 1433
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Received |
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2016-03-07 08:58 |
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Peer-Review Started |
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2016-03-07 11:14 |
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To Make the First Decision |
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2016-05-17 12:16 |
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Return for Revision |
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2016-05-18 10:39 |
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Revised |
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2016-06-01 21:24 |
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Second Decision |
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2016-06-30 08:35 |
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Accepted by Journal Editor-in-Chief |
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2016-06-30 11:26 |
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Accepted by Company Editor-in-Chief |
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2016-07-13 12:06 |
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Articles in Press |
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2016-07-13 12:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-07-27 16:03 |
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Publish the Manuscript Online |
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2016-08-17 08:44 |
ISSN |
1948-5182 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Basic Study |
Article Title |
Interplay between microRNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma
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Manuscript Source |
Invited Manuscript |
All Author List |
Danira Ashraf Habashy, Hend Mohamed El Tayebi, Injie Omar Fawzy, Karim Adel Hosny, Gamal Esmat and Ahmed Ihab Abdelaziz |
Funding Agency and Grant Number |
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Corresponding Author |
Ahmed Ihab Abdelaziz, MD, PhD, Associate Professor of Molecular Medicine, Department of Biology, American University in Cairo, New Cairo City, AUC Avenue, Cairo 11835, Egypt. ahmed.ihab.abdelaziz@gmail.com |
Key Words |
Insulin-like growth factor binding protein-3; Insulin-like growth factor signaling pathway; microRNA; Insulin-like growth factor-Ⅱ; Hepatocellular carcinoma |
Core Tip |
microRNA-17-5p (miR-17-5p) was extensively underexpressed in hepatocellular carcinoma tissues, while insulin-like growth factor binding protein-3 (IGFBP-3) mRNA showed significant upregulation in the same set of patients. In HuH-7 cell line, miR-17-5p directly targets and downregulates IGFBP-3, consequently elevating the level of free insulin-like growth factor-Ⅱ (IGF-Ⅱ). Thus, manipulation of microRNAs can potentially control the activation of the oncogenic IGF axis. |
Publish Date |
2016-08-17 08:44 |
Citation |
Habashy DA, El Tayebi HM, Fawzy IO, Hosny KA, Esmat G, Abdelaziz AI. Interplay between microRNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma. World J Hepatol 2016; 8(23): 976-984 |
URL |
http://www.wjgnet.com/1948-5182/full/v8/i23/976.htm |
DOI |
http://dx.doi.org/10.4254/wjh.v8.i23.976 |
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