BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
8/17/2016 8:44:00 AM | Browse: 1028 | Download: 1433
Publication Name World Journal of Hepatology
Manuscript ID 25383
Country/Territory Egypt
Received
2016-03-07 08:58
Peer-Review Started
2016-03-07 11:14
To Make the First Decision
2016-05-17 12:16
Return for Revision
2016-05-18 10:39
Revised
2016-06-01 21:24
Second Decision
2016-06-30 08:35
Accepted by Journal Editor-in-Chief
2016-06-30 11:26
Accepted by Company Editor-in-Chief
2016-07-13 12:06
Articles in Press
2016-07-13 12:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-07-27 16:03
Publish the Manuscript Online
2016-08-17 08:44
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Interplay between microRNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Danira Ashraf Habashy, Hend Mohamed El Tayebi, Injie Omar Fawzy, Karim Adel Hosny, Gamal Esmat and Ahmed Ihab Abdelaziz
Funding Agency and Grant Number
Corresponding Author Ahmed Ihab Abdelaziz, MD, PhD, Associate Professor of Molecular Medicine, Department of Bio­logy, American University in Cairo, New Cairo City, AUC Avenue, Cairo 11835, Egypt. ahmed.ihab.abdelaziz@gmail.com
Key Words Insulin-like growth factor binding protein-3; Insulin-like growth factor signaling pathway; microRNA; Insulin-like growth factor-Ⅱ; Hepatocellular carcinoma
Core Tip microRNA-17-5p (miR-17-5p) was extensively underexpressed in hepatocellular carcinoma tissues, while insulin-like growth factor binding protein-3 (IGFBP-3) mRNA showed significant upregulation in the same set of patients. In HuH-7 cell line, miR-17-5p directly targets and downregulates IGFBP-3, consequently elevating the level of free insulin-like growth factor-Ⅱ (IGF-Ⅱ). Thus, manipulation of microRNAs can potentially control the activation of the oncogenic IGF axis.
Publish Date 2016-08-17 08:44
Citation Habashy DA, El Tayebi HM, Fawzy IO, Hosny KA, Esmat G, Abdelaziz AI. Interplay between microRNA-17-5p, insulin-like growth factor-Ⅱ through binding protein-3 in hepatocellular carcinoma. World J Hepatol 2016; 8(23): 976-984
URL http://www.wjgnet.com/1948-5182/full/v8/i23/976.htm
DOI http://dx.doi.org/10.4254/wjh.v8.i23.976
Full Article (PDF) WJH-8-976.pdf
Full Article (Word) WJH-8-976.doc
Manuscript File 25383-Review.doc
Answering Reviewers 25383-Answering reviewers.pdf
Audio Core Tip 25383-Audio core tip.mp3
Biostatistics Review Certificate 25383-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 25383-Conflict-of-interest statement.pdf
Copyright License Agreement 25383-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20160306202722.pdf
Institutional Review Board Approval Form or Document 25383-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 25383-Language certificate.pdf
Peer-review Report 25383-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 25383-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 25383-Scientific misconduct check.pdf
Scientific Editor Work List 25383-Scientific editor work list.pdf