Publication Name	World Journal of Gastroenterology
Manuscript ID	2555
Country	China

Received	2013-02-28 16:40
Peer-Review Started	2013-03-01 11:39
To Make the First Decision	2013-03-25 15:24
Return for Revision	2013-04-01 10:27
Revised
Second Decision	2013-05-09 13:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-05-10 10:50
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-02 09:41
Publish the Manuscript Online	2013-07-13 17:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial
Manuscript Source	Invited Manuscript
All Author List	Wei Huang, Shu-Man Jiang, Lin Jia, Le-Qing You, Yao-Xing Huang, Yan-Mei Gong and Gui-Qin Wang
Funding Agency and Grant Number
Corresponding Author	Dr. Lin Jia, Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, No.1 Panfu Road, Guangzhou 510180, Guangdong Province, China. jialin@medmail.com.cn
Key Words	Amitriptyline; Orocecal transit time; Visceral hypersensitivity; Gastric emptying; Brain-gut peptides
Core Tip	Low-dose amitriptyline has been used to treat functional gastrointestinal disorders for many years, but the precise mechanism is still not clear. Brain-gut peptides, such as motilin, ghrelin and neuropeptide Y, may regulate gastrointestinal functions. However, evidence indicating the possible effects of amitriptyline on the levels of brain-gut peptides in healthy Chinese volunteers is limited. In this study, we conclude that low-dose amitriptyline can slow orocecal transit time, make the stomach less sensitive and increase the plasma levels of ghrelin and neuropeptide Y. Thus, we recommend the use of low-dose amitriptyline for functional gastrointestinal disorders.
Publish Date	2013-07-13 17:01
Citation	Huang W, Jiang SM, Jia L, You LQ, Huang YX, Gong YM, Wang GQ. Effect of amitriptyline on gastrointestinal function and brain-gut peptides: A double-blind trial. World J Gastroenterol 2013; 19(26): 4214-4220
URL	http://www.wjgnet.com/1007-9327/full/v19/i26/4214.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i26.4214

Full Article (PDF)	WJG-19-4214.pdf
Manuscript File	2555-Review.doc
Answering Reviewers	2555-Answering reviewers.pdf
Copyright License Agreement	2555-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	伦理审查批件.JPG
Non-Native Speakers of English Editing Certificate	2555-Language certificate.pdf
Peer-review Report	2555-Peer review.pdf
Scientific Editor Work List	2555-Scientific editor work list.doc