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11/7/2016 10:11:00 AM | Browse: 569 | Download: 792
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 25596
Country/Territory India
2016-03-16 08:57
Peer-Review Started
2016-03-18 10:24
To Make the First Decision
2016-05-17 13:48
Return for Revision
2016-05-19 10:29
2016-06-27 00:00
Second Decision
2016-08-08 15:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2016-08-16 14:01
Articles in Press
2016-08-16 14:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-10-27 12:08
Publish the Manuscript Online
2016-11-07 10:11
ISSN 2219-2808 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pediatrics
Manuscript Type Systematic Reviews
Article Title Zinc supplementation as an adjunct to standard therapy in childhood nephrotic syndrome - a systematic review
Manuscript Source Invited Manuscript
All Author List Girish Chandra Bhatt, Shikha Jain and Rashmi Ranjan Das
Funding Agency and Grant Number
Corresponding Author Rashmi Ranjan Das, MD, Department of Pediatrics, All India Institute of Medical Sciences, SIJUA, Bhubaneswar 751019, India. rrdas05@gmail.com
Key Words Nephrotic syndrome; Pediatric; Relapse; Zinc; Micronutrient
Core Tip Relapses in nephrotic syndrome (NS) increase morbidity and mortality. Studies have shown that zinc deficiency is common in NS. Zinc defi-ciency might lead to down-regulation of T-helper 1 (Th1) cytokines, a relative T-helper 2 (Th2) bias, and an increased risk of infection. The later commonly associated with relapse in NS. Zinc supplementation restores Th1-Th2 im-balance and may decrease relapse. The primary aim of this review is to evaluate the efficacy of zinc in preventing relapses in childhood NS (steroid sensitive and steroid dependent/frequent relapsing). The secondary aim is to evaluate the safety of zinc supplementation in this regard.
Publish Date 2016-11-07 10:11
Citation Bhatt GC, Jain S, Das RR. Zinc supplementation as an adjunct to standard therapy in childhood nephrotic syndrome - a systematic review. World J Clin Pediatr 2016; 5(4): 383-390
URL http://www.wjgnet.com/2219-2808/full/v5/i4/383.htm
DOI http://dx.doi.org/10.5409/wjcp.v5.i4.383
Full Article (PDF) WJCP-5-383.pdf
Full Article (Word) WJCP-5-383.doc
Manuscript File 25596-Review.doc
Answering Reviewers 25596-Answering reviewers.pdf
Audio Core Tip 25596-Audio core tip.mp3
Biostatistics Review Certificate Biostatistics_Statement_20160316015952.doc
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20160316015735.doc
Conflict-of-Interest Disclosure Form 25596-Conflict-of-interest statement.pdf
Copyright License Agreement 25596-Copyright assignment.pdf
Data Sharing Statement 25596-Data sharing statement.pdf
Non-Native Speakers of English Editing Certificate 25596-Language certificate.pdf
Supplementary Material Supplementary_Material_20160316014758.jpg
Peer-review Report 25596-Peer-review(s).pdf
Scientific Misconduct Check 25596-Scientific misconduct check.pdf
Scientific Editor Work List 25596-Scientific editor work list.pdf